Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
By J. Shimizu, S. Yamazaki, Takeshi Takahashi, Y. Ishida, Shimon Sakaguchi. Nature Immunology, 2002
1,926 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/45bc39c5f4cc99ec81d8c5adcc19229ef596a493
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In Immunology
- Shimon Sakaguchi
- Alexander Y. Rudensky
- Steven Z. Josefowicz
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Citations in the corpus
- Natural selection of tumor variants in the generation of “tumor escape” phenotypes (2002, background): “Identification of the glucocorticoid-induced TNF receptor family–related gene (GITR, also known as TNFRSF18) expressed on T regulatory cells might afford new therapeutic opportunities, as stimulation of GITR with an activating antibody reverses CD4 + CD25 + T cell–mediated suppressio”
- Regulatory T cells and immune tolerance. (2008, background): “Stimulation of GITR, which is constitutively expressed in Tregs at a higher level than in other T cells, facilitates vigorous proliferation of Tregs in the presence of IL-2 in vitro (McHugh et al., 2002; Shimizu et al., 2002).”
- A two-step process for thymic regulatory T cell development. (2008, methodology): “For these in vivo experiments, we avoided the use of anti-GITR DTA-1 monoclonal antibody because of its potentially activating properties in vivo (Shimizu et al., 2002).”
- Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. (2005, background): “Therefore, we decided to include other, more specific surface markers, such as GITR, HLA-DR, CD45RO, CD152, and CD45RA, to identify regulatory T cells by flow cytometry (26, 27).”
- T Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis (2012, background): “effector functions, renders Teff cells resistant to Tregs, and enhances a variety of T-cell responses (109, 110).”
- Mechanisms of suppression by suppressor T cells (2005, background): “In fact, in gene expression screens, CD4 + CD25 + suppressor T cells show increased expression of the glucocorticoid-inducible TNF receptor (GITR”
- Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State (2003, background): “Besides its constitutive expression of CD25, natural suppressor CD4� T cells have been described by various phenotypes such as CD5high (37), GITR� (35, 38 ), CD38� (39), or CD45RBlow (40) cells.”
- Regulatory T cells and mechanisms of immune system control (2004, neutral): “and glucocorticoid-induced tumor necrosis factor recepto”