Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma.

By Lars A. Ormandy, Tina Hillemann, H. Wedemeyer, M. Manns, T. Greten, F. Korangy. Cancer Research, 2005

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Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. (2007, background): “in both peripheral blood and the tumor microenvironment in HCC, and Tregs from HCC can suppress proliferation and perforin expression of autologous T cells in vitro.(11,27,28) After removal of the tumors, elevated levels of circulating Tregs subsided.”
Regulatory T cells in cancer. (2006, background): “Increased numbers of Treg cells have also been reported in PB and TIL of patients with hepatocellular carcinoma.(78) While the increase of Treg cells seems to be a common theme in solid tumors, there are clear but yet unexplained differences between individual tumor entities.”
Genetics and biology of prostate cancer (2018, background): “In many human tumor types, immunosuppressive FoxP3 Tregs are present in the TME (Woo et al. 2002; Ormandy et al. 2005; Chaudhary and Elkord 2016) and suppress effector T-cell responses (Josefowicz et al.”
Advances in immunotherapy for hepatocellular carcinoma (2021, background): “I.M. receives funding from MINECO SAF2014-52361-R and SAF 2017- 83267-C2-1R; Worldwide Cancer Research Grant (15-1146); the Asociacion Española Contra el Cancer (AECC) Foundation under grant GCB15152947MELE; and the European Union’s Horizon 2020 Program (grant agreement no. 635122 PROCROP).”