EMT, MET, plasticity and tumor metastasis

By Basil Bakir, Anna M. Chiarella, Jason R. Pitarresi, A. Rustgi. Trends in Cell Biology, 2020

831 citations recorded by the source corpus.

Cancer cell identity and plasticity are required in transition states, such as epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), in primary tumor initiation, progression and metastasis. The functional roles of EMT, MET and partial state (referred to as p-EMT) may vary based upon the type of tumor, state of dissemination and degree of metastatic colonization. Herein, we review EMT, MET, pEMT and plasticity in the context of tumor metastasis.

Subfields: Oncology

View Paper: https://www.semanticscholar.org/paper/40afcaaa67fbf4df3a34355accc9c54fccb1ff86

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In Oncology

1. Yuhe Huang
2. Xiawei Wei
3. Weiqi Hong

Citations in the corpus

• The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “EMT and circulating tumor cells Circulating tumor cells (CTCs) are cancer cells that have spread from the primary tumor to various organs through the vascular or lymphatic system [205].”