The ins and outs of the epithelial to mesenchymal transition in health and disease.
By M. Nieto. Annual Review of Cell and Developmental Biology, 2011
732 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/13bef98877246ccbe9c5114607540b43fb76ab24
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Citations in the corpus
- TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression (2013, background): “Finally, the cells acquire invasive properties through increased expression and secretion of metalloproteases (MMPs), and cells that underwent EMT are also efficiently capable of synthesizing components of the ECM to reconstitute their microenvironment following cell invasion [15,18,19].”
- Epithelial-Mesenchymal Plasticity: A central regulator of cancer progression (2015, background): “…cells are determined by differences in their respective transcription programs, which control, among other gene products, the expression of key structural proteins, including those involved in maintaining the cytoskeleton and in forging cell-cell adhesions (Nieto, 2011, 2013; Thiery et al., 2009).”
- TGF-β1 Signaling and Tissue Fibrosis. (2018, background): “EMT occurs early in embryogenesis during gastrulation, as epiblasts migrate to form the primitive streak, move to the interior of the blastocyte, and form the mesodermal germ layer (Nieto et al. 1994; Viebahn 1995; Viebahn et al. 1995; Nieto 2011).”
- Epithelial-mesenchymal transitions: insights from development (2012, background): “…cell polarity proteins and effector proteins have been shown to govern EMT in normal and transformed epithelial cells (see Table 1), suggesting that novel mechanisms govern EMT (Peinado et al., 2007; Moustakas and Heldin, 2009; Thiery et al., 2009; Nieto, 2011; Valastyan and Weinberg, 2011).”
- Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells (2013, background): “Because EMT may be extremely deleterious when aberrantly activated in the adult (3), it needs to be very tightly regulated to ensure epithelial homeostasis.”