Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.

By A. V. van Beelen, Z. Zelinkova, Esther W M Taanman-Kueter, F. Muller, D. Hommes, S. Zaat, M. Kapsenberg, E. D. de Jong. Immunity, 2007

601 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/449c42e46d89f7f006540062729a2dc9e316d031

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Tschopp
2. T. Mogensen
3. G. Núñez
4. V. Kuchroo
5. E. Latz
6. Katherine A. Fitzgerald
7. L. Franchi
8. T. Korn

Citations in the corpus

• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “In addition, MDP enhances the differentiation of CD4 T cells into T-helper 17 (Th17) cells (103).”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “functions in protection against certain bacterial infections and with possible roles in the development of autoimmunity was discovered (286, 372).”
• A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses (2008, result): “Two other studies were not able to differentiate naive CD4 T cells into T H -17 cells, even with conditions shown to be efficient in mouse or human system”
• Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome (2010, background): “However, the exact interaction of NOD2, NF-κB and pro-IL-1β/IL-1β remains a matter of debate.”
• IL-17 and Th17 Cells. (2009, background): “Indeed, when DCs lack the NLR protein NOD2, they are impaired in their capacity to secrete IL-23 (102).”
• Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. (2009, background): “However, naive murine T cells do not express IL-23R and do not differentiate into Th17 cells in response to IL-23 in vitro (Langrish et al., 2005; van Beelen et al., 2007).”
• Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome (2012, background): “Interleukin 1β (IL-1β) is an important proinflammatory cytokine that is required for the induction of immune responses involving IL-17-producing helper T cells (T H 17 cells”