Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells.

By E. Zigmond, C. Varol, J. Farache, Elinor Elmaliah, Ansuman T. Satpathy, G. Friedlander, M. Mack, Nahum Shpigel, I. Boneca, K. Murphy and 3 more. Immunity, 2012

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Subfields: Immunology

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The Cellular and Molecular Origin of Tumor-associated Macrophages (2014, unknown): “Additionally, bone marrow-derived monocytes give rise to macrophages in the intestine and the dermis (6, 7) as well as during acute infection and inflammation (8).”
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment (2014, methodology): “Tissue Processing, Flow Cytometry, and Cell Sorting Macrophages were purified following protocols (Extended Experimental Procedures; Data S1) as previously described (Gautier et al., 2012b; Zigmond et al., 2012).”
Tissue-Resident Macrophage Ontogeny and Homeostasis. (2016, background): “…that macrophage populations in these sites are significantly reduced in mice lacking this chemokine receptor (Bain et al., 2014; Platt et al., 2010; Zigmond et al., 2012) and originate almost exclusively from wild-type BM-derived cells in WT:Ccr2 / competitive chimeras (Tamoutounour et al., 2013).”
Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases (2014, background): “Several studies revealed “unusual” cascades of monocytes to macrophage transition: 1) Infiltrated Ly6C monocytes in inflamed skeletal muscle or brain tissues acquire phenotypic features of anti-inflammatory monocytes by down-regulating Ly6C expression, thereby displaying anti-inflammatory M2 macroph”