Atg8 controls phagophore expansion during autophagosome formation.

By Zhiping Xie, Usha Nair, D. Klionsky. Molecular Biology of the Cell, 2008

768 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/41bdc6206c43f85d3ee1c88bc20be97c5b64ed29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. D. Klionsky
2. Beth Levine
3. N. Mizushima
4. V. Deretic
5. T. Johansen
6. I. Slaninová
7. Zhifen Yang
8. Yongqiang Chen

In Epidemiology

1. D. Klionsky
2. Beth Levine
3. N. Mizushima
4. I. Slaninová
5. Guido Kroemer
6. V. Deretic
7. T. Johansen
8. T. Lamark

In Physiology

1. D. Klionsky
2. Katherine R Parzych
3. Alec C. Kimmelman
4. Beth Levine
5. M. Jäättelä
6. Guillermo Mariño
7. Yongqiang Chen
8. M. Høyer-Hansen

Citations in the corpus

• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “estimate the size range and the number of spherical objects by profiles in sections;(111) however, such methods have been used in autophagy research only a few times.(32,107,113,114)”
• FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport (2010, background): “In yeast, Atg8 localizes to phagophores and autophagosomes, where it participates in membrane expansion (Kirisako et al., 1999; Xie et al., 2008).”
• Dynamics and diversity in autophagy mechanisms: lessons from yeast (2009, background): “Similar consequences are also observed when the expression level of Atg8 is genetically engineered to be decrease”
• Atg32 is a mitochondrial protein that confers selectivity during mitophagy (2009, background): “Atg8 determines the size of nonselective autophagosomes (Xie et al., 2008) and accumulates at the PAS during autophagy.”
• Ubiquitination and selective autophagy (2012, background): “Furthermore, LC3 may also control the size of autophagosomes.(49)”
• An Overview of the Molecular Mechanism of Autophagy (2009, background): “A quantitative correlation between the amount of Atg8 and the size of the sequestering vesicle has recently been determined (Xie et al. 2008).”
• LC3 and GATE‐16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis (2010, background): “In yeast, Atg8 has a crucial role in the autophagic process possibly in the elongation of the phagophore membrane by mediating hemi-fusion events (Abeliovich et al, 2000; Nakatogawa et al, 2007; Xie et al, 2008).”
• The regulation of autophagy – unanswered questions (2011, background): “, 2007), and the amount of Atg8 determines the size of autophagosomes (Xie et al., 2008).”
• ER stress-induced cell death mechanisms. (2013, background): “It is distributed symmetrically on both sides of the autophagosome and it is assumed that there is a quantitative correlation between the amount of Atg8 and the vesicle size [54].”
• Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “The advantage of this approach is that it can provide accurate information on flux even when the autophagosomes are abnormally small.(63,64) Thus, although a high frequency of “abnormal” structures presents a challenge, TEM is still very helpful in analyzing autophagy.”
• An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “Atg8, and to some extent LC3 (92, 138), shows a substantial increase in synthesis during macroautophagy induction (72), and in yeast this is a determining factor in autophagosome size (149).”