Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

By M. Arita, F. Bianchini, J. Aliberti, A. Sher, Chia Nan, Song Hong, Rong Yang, N. Petasis, C. Serhan. Journal of Experimental Medicine, 2005

952 citations recorded by the source corpus.

The essential fatty acid eicosapentaenoic acid (EPA) present in fish oils displays beneficial effects in a range of human disorders associated with inflammation including cardiovascular disease. Resolvin E1 (RvE1), a new bioactive oxygenated product of EPA, was identified in human plasma and prepared by total organic synthesis. Results of bioaction and physical matching studies indicate that the complete structure of RvE1 is 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA. At nanomolar levels, RvE1 dramatically reduced dermal inflammation, peritonitis, dendritic cell (DC) migration, and interleukin (IL) 12 production. We screened receptors and identified one, denoted earlier as ChemR23, that mediates RvE1 signal to attenuate nuclear factor–κB. Specific binding of RvE1 to this receptor was confirmed using synthetic [3H]-labeled RvE1. Treatment of DCs with small interference RNA specific for ChemR23 sharply reduced RvE1 regulation of IL-12. These results demonstrate novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation.

Subfields: Biochemistry, Nutrition and Dietetics, Pharmacology

View Paper: https://www.semanticscholar.org/paper/3ee22bc8d2a334f54a481874f5244ad85a06f155

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. C. Serhan
2. N. Petasis
3. Oliver Soehnlein
4. Undurti N. Das
5. D. Gilroy
6. Chia Nan
7. C. Buckley
8. R. Ji

In Nutrition and Dietetics

1. C. Serhan
2. D. Gilroy
3. N. Petasis
4. Oliver Soehnlein
5. Undurti N. Das
6. Chia Nan
7. C. Buckley
8. R. Ji

In Pharmacology

1. C. Serhan
2. T. Berta
3. R. Ji
4. Undurti N. Das
5. Chia Nan
6. N. Petasis
7. Oliver Soehnlein
8. L. Lindbom

Citations in the corpus

• Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation (2014, background): “, 1997), the concept of COX inhibition, and hence lipid mediator manipulation in severe inflammatory states, is regaining traction (Aronoff, 2012; Eisen, 2012).”
• Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis (2007, background): “RvE1 can block the production of proinflammatory cytokines when it binds to the receptor ChemR23 (refs”
• Resolvin D1 binds human phagocytes with evidence for proresolving receptors (2010, methodology): “RvE1 stimulates proresolution pathways via ChemR23, which is abundantly expressed in MΦ and dendritic cells (10), whereas it binds to BLT1 for its anti-PMN actions (11).”
• Phagocyte partnership during the onset and resolution of inflammation (2010, background): “Ligation of the pro-inflammatory leukotriene B 4 receptor BLT1 on neutrophils by resolvin E1 has antagonizing effect”
• Essential fatty acids: biochemistry, physiology and pathology (2006, background): “Aspirin can convert AA, EPA and DHA to what is called as aspirin-triggered 15 epimer LXs (ATLs), which are potent inhibitors of acute inflammation [49, 84, 85].”
• Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs. (2015, background): “RvE1 Reduces dermal inflammation, peritonitis, dendritic cell migration, and IL-12 production in an inflammatory mouse model (305) Reduces total leukocytes and PMN infiltration in murine peritonitis (306) Reduces hepatic fibrosis in murine model of infection (307) Promotes phagocyte removal during a”
• Resolvins RvE1 and RvD1Attenuate Inflammatory Pain via Central and Peripheral Actions (2010, positive): “ChemR23, which is associated with the G protein subunit G α i, has been identified as RvE1's recepto”