Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements.

By K. Setchell, N. Brown, P. Desai, L. Zimmer‐Nechemias, Brian E Wolfe, W. Brashear, Abby S. Kirschner, A. Cassidy, J. Heubi. Journal of NutriLife, 2001

922 citations recorded by the source corpus.

Subfields: Genetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/3eaf3eebaa5df24e73c19d41ba84fd20bb5bbd50

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In Genetics

1. Claudine Manach
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Citations in the corpus

• Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. (2005, background): “Consumption of isoflavone-rich foods or of the purified isoflavones themselves leads to appearance in the plasma, with a peak of absorption at 6–8 h (7).”
• Polyphenols, dietary sources and bioavailability. (2007, background): “However few data on the proportions of the various type of conjugates and the percentages of free forms in plasma are available [74, 109, 120-124].”
• The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. (2002, methodology): “Thus, glycitein is not converted to any appreciable extent to daidzein and is therefore not a precursor of equol (40,48).”
• Bioactivity of dietary polyphenols: The role of metabolites (2020, background): “The oral bioavailability of isoflavones as glycosylated forms or free aglycons is still on debate (Setchell et al. 2001; Richelle et al. 2002).”
• Green Synthesis and Characterization of Gold Nanoparticles Using Onion ( Allium cepa ) Extract (2011, background): “The power of phytochemicals, which initiate varieties of chemical transformations within biological systems, is well known [12, 14-16].”
• Polyphenols: food sources and bioavailability. (2004, methodology): “Setchell et al (101) showed that when pure daidzein, genistein, or their corresponding 7-glucosides were administered orally to healthy volunteers, a tendency toward greater bioavailability was observed with the glucosides, as measured from the area under the curve of the plasma concentrations: 2.94”
• The pros and cons of phytoestrogens (2010, neutral): “dietary supplements [250,217] typically at far higher concentrations than found in soy-based foods.”
• Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. (2002, methodology): “Total and free (unconjugated) isoflavone concentrations were previously measured in the samples from these subjects with the use of gas chromatography–mass spectrometry (GC-MS), and these were reported elsewhere (24).”
• Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. (2005, methodology): “In contrast, equol production was significantly higher after ingestion of daidzin than after ingestion of daidzein (112, 117).”
• Timing of supplementation of selenium and isoflavones determines prostate cancer risk factor reduction in rats (2008, positive): “Analysis of serum isoflavone content was performed as described previously [52].”