Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability.

By K. Setchell, N. Brown, L. Zimmer‐Nechemias, W. Brashear, Brian E Wolfe, Abby S. Kirschner, J. Heubi. American Journal of Clinical Nutrition, 2002

627 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Pathology and Forensic Medicine, Rheumatology

View Paper: https://www.semanticscholar.org/paper/bdebdf2810663ea733418fba19a04e9cee52adf5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Jianbo Xiao
2. Augustin Scalbert
3. G. Beecher

In Pathology and Forensic Medicine

1. Augustin Scalbert
2. Claudine Manach
3. Jianbo Xiao
4. G. Williamson
5. S. Ramos
6. J. Dai
7. R. Mumper

Citations in the corpus

• Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. (2005, background): “Glycosides are hydrolyzed before absorption and are not recovered as such in plasma (122).”
• Microbial β-Glucosidase: Sources, Production and Applications (2017, background): “Naturally, majority of these compounds are presents in form of glycosides which increase their water solubility and stability and limit their absorption from human GIT [248].”
• The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility (2016, background): “As they are able to bind to estrogen receptors (ERα and ERβ), they are classified as natural selective estrogen receptor modulators (SERMs) [65–70].”
• Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases (2013, positive): “(410) detected urinary isoflavones as deglycosylated sulfates and glucuronides, implying the involvement of intestinal metabolism in their bioavailability.”