Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

By E. Nisoli, C. Tonello, A. Cardile, Valeria Cozzi, R. Bracale, L. Tedesco, S. Falcone, A. Valerio, O. Cantoni, E. Clementi and 2 more. Science, 2005

1,142 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/3c2f14ca227e00fe79000e630c6057dd772ef3df

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. M. Haigis
2. D. Sinclair
3. L. Guarente
4. E. Verdin
5. S. Mitchell
6. Joseph A. Baur
7. Bor Luen Tang
8. Michael Ristow

In Geriatrics and Gerontology

1. D. Sinclair
2. M. Haigis
3. L. Guarente
4. Bor Luen Tang
5. E. Verdin
6. Joseph A. Baur
7. Danica Chen
8. Michael Ristow

In Physiology

1. D. Sinclair
2. Bor Luen Tang
3. M. Haigis
4. E. Verdin
5. L. Guarente
6. Joseph A. Baur
7. Danica Chen
8. M. Hirschey

Citations in the corpus

• A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice (2008, background): “Previous studies in rats [23] and humans [24] suggest that CR induces SIRT1 in these species, but the only study in mice that addressed this issue used an ‘‘every other day’’ feeding protocol, and therefore does not represent CR [31].”
• Caloric restriction. (2011, background): “A second signaling system implicated in the immediate activity response is the orexin (hypocretin) system (Novak et al., 2005).”
• Extending life span by increasing oxidative stress. (2011, background): “Furthermore, CR promotes mitochondria biogenesis and OxPhos in rodents as well as enhancement of respiratory capacity in mammalian cells [114,115].”
• Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. (2010, background): “Although mitochondrial activity is increased by CR (Nisoli et al., 2005), oxidative stress and damage are reduced in CR animals (Merry, 2004).”
• Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “Interestingly, caloric restriction-induced mitochondrial biogenesis in heart is accompanied by increased SIRT1 expression in wild-type but not eNOS mice.(49) These results again indicate that mitochondrial biogenesis is strictly controlled in the heart.”
• Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. (2006, background): “Interestingly, the SIRT1 gene is activated by NO in vivo and in vitro (Nisoli et al. 2005), tracing a pathway in which CR induces NO production and activates mitochondrial biogenesis and SIRT1.”
• Translational regulation of gene expression during conditions of cell stress. (2010, background): “, 2007), and under nutrient depletion in mammals there is an increase in mitochondrial biogenesis (Nisoli et al., 2005).”
• Transcriptional control of mitochondrial biogenesis and function. (2009, background): “Mice lacking eNOS, an NO-producing enzyme that is induced by caloric restriction, show mitochondrial defects in multiple tissues (135).”
• How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). (2010, background): “Similarly, however analyzing global CR (and not specifically glucose restriction), it was shown that food deprivation promotes mitochondrial biogenesis and OxPhos in rodents (Nisoli et al., 2005).”
• The role of mitochondria in aging. (2013, positive): “and caloric restriction (CR) can reduce oxidative damage and improve mitochondrial function (36, 37).”
• Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? (2007, background): “Similarly, mitochondrial biogenesis is increased in tissues from calorie-restricted mice, which is probably due to the increased transcription of nuclear-encoded mitochondrial gene”