Innate immune recognition: mechanisms and pathways

By R. Medzhitov, CharleS. Jr Janeway. Immunological Reviews, 2000

1,572 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3bc530a538e0652e22d24c7d6ba268d5afc34b4b

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In Immunology

Citations in the corpus

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 (2001, background): “Toll-like receptors (TLRs) recognize PAMPs and mediate the production of cytokines necessary for the development of effective immunit”
Adenoviruses as vaccine vectors (2004, neutral): “PAMPs bind to pathogen recognition receptors on host cells, including those of the innate immune system, thus initiating production of proinflammatory cytokines and differentiation of immature dendritic cells into professional antigen-presenting cells [22].”
Trained immunity: a program of innate immune memory in health and disease (2016, background): “Finally, the concept of innate immune memory has considerable potential in helping the design of novel therapeutic approaches, with at least three potential lines of investigation: (1) the design of new generation vaccines that combine adaptive and innate immune memory, as recently proposed with a n”
International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family (2009, methodology): “The photoaffinity-labeled receptor was then purified through the interaction of its biotin moiety with streptavidin-coated beads.”
Unified Polymerization Mechanism for the Assembly of ASC-dependent Inflammasomes (2014, background): “Innate immunity offers the first line of defense against infections and hazards by directly recognizing conserved pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) to alert the immune system (Medzhitov and Janeway, 2000).”
Toll-like receptors in systemic autoimmune disease (2006, background): “Although PRRs were initially identified as receptors that distinguish microbial molecular structures from host tissue”
Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα (2001, background): “The NF-kB transcription factor family plays an evolutionarily conserved role in innate and adaptive immune responses, and its members are essential regulators of proinflammatory processes (12, 18, 33).”
Mouse and human dendritic cell subtypes (2002, background): “The receptors that recognize these diverse stimuli vary from lectin-domain scavenger receptors that are similar to those on phagocytes to the Toll-like receptors (TLRs), which are related to proteins from the defence systems of plants and insect”
Broad Expression of Toll‐Like Receptors in the Human Central Nervous System (2002, background): “TLRs recognize a wide variety of pathogen-associated molecular patterns (PAMP) such as peptidoglycan, liposaccharide (LPS), bacterial DNA, and double-stranded RNA (1).”