The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

By F. Hayashi, Kelly D. Smith, A. Ozinsky, T. Hawn, E. Yi, D. Goodlett, Jimmy K. Eng, Shizuo Akira, D. Underhill, Alan Aderem. Nature, 2001

3,715 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology

View Paper: https://www.semanticscholar.org/paper/afd173b60e0b88478e03f0d803673bf1c71f9a8f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. Shizuo Akira
2. O. Takeuchi
3. S. Ghosh
4. P. Sansonetti
5. G. Barton
6. Jonathan C. Kagan
7. J. Galán
8. S. Lebeer

In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. Taro Kawai
4. O. Takeuchi
5. K. Takeda
6. S. Ghosh
7. Satoshi Uematsu
8. Jonathan C. Kagan

Citations in the corpus

• The multifarious, multireplicon Burkholderia cepacia complex (2005, background): “Bacterial flagellin is the only known ligand that is recognized by Toll-like receptor 5 (TLR5) (Ref”
• TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway (2003, background): “TLR6 is required for recognition of diacylated lipoprotei”
• TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β (2008, background): “org/molecule/query;jsessionid=c6ca4bf1229c7dc88ea4e8d348b48a06cb7293ba80ce?afcsid=A002296">A002296 ) and TLR5 all recognize different components of a bacterial cell wall and, appropriately, are found on the cell surface, where they induce the production of proinflammatory cytokines after the detecti”
• The Transcriptional Innate Immune Response to flg22. Interplay and Overlap with Avr Gene-Dependent Defense Responses and Bacterial Pathogenesis1[w] (2004, background): “For instance, in mice, the innate immune response is activated through perception of the Salmonella flagellin by the TLR5 receptor (Hayashi et al., 2001).”
• Pathogen recognition and innate immunity. (2006, neutral): “TLR5 is responsible for the detection of flagellin and specifically recognizes the constant domain D1, which is relatively conserved among different species (Hayashi et al., 2001).”
• Innate immunity: the missing link in neuroprotection and neurodegeneration? (2002, background): “Flagellin, the principal element of bacterial flagella, is a highly virulent molecule that is recognized by the TLR5 recepto”