Vertebrate Smoothened functions at the primary cilium

By K. Corbit, P. Aanstad, Veena Singla, Andrew R. Norman, D. Stainier, Jeremy F. Reiter. Nature, 2005

1,492 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3abc9d6033405ac823a4b29052986cbd2dab18e5

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Citations in the corpus

The Primary Cilium: A Signaling Center During Vertebrate Development (2010, background): “Two transmembrane proteins, PTCH1 (the Hh receptor) and SMO (which acts downstream of PTCH1), show dynamic, Hh-dependent trafficking in cili”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, neutral): “The primary cilium also functions as an antenna for specific signaling pathways – this structure has been implicated in Hedgehog (Hh), Wnt, and PDGF signaling, which are thought to occur in this region (Corbit et al., 2005; Jackson et al., 2006; Eggenschwiler and Anderson, 2007; Rohatgi et al., 2007”
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, background): “With regard to Hh signaling, previous studies (Corbit et al., 2005; Haycraft et al., 2005; Huangfu and Anderson, 2005; Liu et al., 2005; May et al., 2005) have found that numerous proteins associated with cilia function (intraflagellar transport proteins) play a role in transduction of Hh signaling,”
The graded response to Sonic Hedgehog depends on cilia architecture. (2007, background): “Smoothened (Smo), a transmembrane protein that is essential for Hh signaling, is enriched in the cilia of Hh responding cells in the mouse embryo (Corbit et al., 2005).”
The Primary Cilium as a Complex Signaling Center (2009, background): “Once Hh binding occurs, Ptch is internalized from the cilia membrane while Smo translocates into the cilium [60,63].”
Hedgehog Signaling in Development and Cancer (2008, neutral): “Ciliary localization of Smo correlates with Hh pathway activation: both an oncogenic Smo mutation and Smo agonists, such as SAG and oxysterols, promoted accumulation of Smo in the cilia (Corbit et al., 2005; Rohatgi et al., 2007).”
Mechanical control of stem cell differentiation (2008, background): “Primary cilia are receiving increasing attention following the discovery that these structures play key roles in controlling the Hedgehog signaling pathway (Huangfu and Anderson, 2005; Corbit et al., 2005), one of the major determinants of embryonic patterning (Ingham and McMahon, 2001; Hirokawa et ”
Targeting the Hedgehog pathway in cancer (2006, background): “to which SMOH and other downstream pathway components need to transit in order to achieve activation of Gli transcription factors, the Ci orthologue”
A Transition Zone Complex Regulates Mammalian Ciliogenesis and Ciliary Membrane Composition (2011, background): “Many Hh pathway components, including Patched1 (Ptch1), Smoothened (Smo), Sufu and Gli transcription factors, localize to cilia, and ciliary translocation of Smo is required to robustly activate the pathwa”
Centrioles, centrosomes, and cilia in health and disease. (2009, background): “Subsequently, several mouse mutations initially identified on the basis of a failure in sonic hedgehog (shh) signaling were also found to reside in genes encoding proteins required for IFT (Corbit et al., 2005; Huangfu et al., 2003).”