Targeting the Hedgehog pathway in cancer

By L. Rubin, F. Sauvage. Nature reviews. Drug discovery, 2006

1,031 citations recorded by the source corpus.

Subfields: Molecular Biology, Oral Surgery, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/fd4eb4e01641fd84b57d7db49f0d467dd93df4f6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Auld

Citations in the corpus

• High-throughput screening assays for the identification of chemical probes. (2007, background): “For instance, signaling mediated by Hedgehog, Wnt and Notch proteins uses unconventional proteins implicated in developmental and disease processes, making these pathways important therapeutic target”
• The role of the Hedgehog signaling pathway in cancer: A comprehensive review. (2017, background): “GliA then migrates to the nucleus and activates the expression of the target genes (Figure 1B) [22].”
• Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (2011, background): “Other synthetic small molecules that are more potent inhibitors of Smo have been described”