The Primary Cilium as a Complex Signaling Center
By N. Berbari, A. K. O’Connor, Courtney J. Haycraft, B. Yoder. Current Biology, 2009
613 citations recorded by the source corpus.
Respect for the primary cilium has undergone a remarkable renaissance over the past decade, and it is now thought to be an essential regulator of numerous signaling pathways. The primary cilium’s functions range from the movement of cells and fluid, to sensory inputs involved with olfaction and photoreception. Disruption of cilia function is involved in multiple human syndromes collectively called ‘ciliopathies’. The cilium’s activities are mediated by targeting of receptors, channels, and their downstream effector proteins to the ciliary or basal body compartment. These combined properties of the cilium make it a critical organelle facilitating the interactions between the cell and its environment. Here we review many of the recent advances contributing to the ascendancy of the primary cilium and how the extraordinary complexity of this organelle inevitably assures many more exciting future discoveries.
Subfields: Cell Biology, Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/053626842eab3dbbb7eba5b66c60205f508428cb
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- Insights into Ciliary Genes and Evolution from Multi-Level Phylogenetic Profiling (2017, background): “However, since the discovery of its implication in human diseases (Pazour et al. 2000), its functional roles have been deeply investigated and it is now considered as an essential extracellular sensor allowing integration of chemical, osmotic, mechanical or optical signals (Berbari et al. 2009).”
- Non‐syndromic retinitis pigmentosa (2018, neutral): “In contrast, primary cilia are present on the vast majority of non-motile eukaryotic cells and serve as sensory “antennae” in most sensory organs (Berbari et al., 2009; Singla and Reiter, 2006).”
- Ciliogenesis: building the cell's antenna (2011, background): “Cilia also act as 'antennae' to sense extracellular signals, such as growth factors, hormones, odorants and developmental morphogen”