The Primary Cilium: A Signaling Center During Vertebrate Development
By S. Goetz, K. Anderson. Nature reviews genetics, 2010
1,858 citations recorded by the source corpus.
The primary cilium has recently stepped into the spotlight, as a flood of data show that this organelle has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for hedgehog signal transduction. The formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The cilium therefore represents a nexus for signalling pathways during development. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8a8fc6523dcde2916767fdc344baaa83a2d07981
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Citations in the corpus
- The role of the Hedgehog signaling pathway in cancer: A comprehensive review. (2017, background): “GliR binds to Hh target gene promoters and keeps Hh target genes switched off (Figure 1A) [20].”
- Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice (2015, background): “All these processes are closely linked to Hh signaling, and most CNS-related ciliopathies appear to be associated with altered Hh signaling (9).”
- Gli proteins in development and disease. (2011, background): “Hh signal transduction in vertebrates requires the integrity of a microtubule-based organelle called the primary cilium that bulges out of the surface of quiescent cells (for a review, see Goetz & Anderson 2010).”