Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

By Jongdae Lee, T. Chuang, V. Redecke, Liping She, P. Pitha, D. Carson, E. Raz, H. Cottam. Proceedings of the National Academy of Sciences of the United States of America, 2003

619 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3a96b36679a4d4771b60a596545fd9158816a326

How researchers see this paper

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In Immunology

1. Shizuo Akira
2. A. Lanzavecchia
3. Yong‐jun Liu
4. F. Sallusto
5. G. Trinchieri
6. E. Latz
7. M. Colonna
8. Katherine A. Fitzgerald

Citations in the corpus

• Dendritic-cell control of pathogen-driven T-cell polarization (2003, neutral): “In addition, TLR7 is ligated by guanosine analogue”
• Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8 (2005, neutral): “Functionally, TLR7 and TLR8 are thought to form a subgroup within the TLR family that recognizes pathogen-associated molecular patterns in endosomal/lysosomal compartments (31).”
• Plasmacytoid dendritic cells in immunity (2004, background): “This observation, along with the structural homology between some TLR7 ligands and ribonucleotide”
• TLR9 signals after translocating from the ER to CpG DNA in the lysosome (2004, background): “Although this mechanism of cellular activation seems to be unique, TLR9 shares many properties with TLR7 and TLR8 (ref”
• Toll-like receptor control of the adaptive immune responses (2004, neutral): “These TLRs are localized to intracellular compartment”
• Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells (2006, background): “, another report raised the possibility that commensal bacteria induce an active export of NF-κB molecules from the nucleus through peroxisome proliferator-activated receptor γ (PPARγ”
• Toll‐like receptors control autophagy (2008, background): “TLR7 stimulation activates autophagy via MyD88 As all known effector functions of TLR7 signalling depend on the MyD88 adapter protein (Lee and Kim, 2007), we next tested whether MyD88 was required for TLR7 induction of autophagy (Figure 6A–”
• LPS, TLR4 and infectious disease diversity (2005, background): “Recognition of these ligands can occur both on the cell surface and inside the cell (for example, in late endosomes), depending on the subcellular localization of each individual TL”
• Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells (2005, background): “Mouse bone marrow–derived DCs do not express TLR8 but express the homologous receptors TLR7 and TLR9 (ref”