Review article: the role of butyrate on colonic function

By H. Hamer, D. Jonkers, K. Venema, S. Vanhoutvin, F. Troost, R. Brummer. Alimentary Pharmacology and Therapeutics, 2007

2,633 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/3a94df074e2c6eed25202014a31521550de144b2

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In Molecular Biology

1. J. Cryan
2. P. Louis
3. H. Flint
4. Ted G. Dinan
5. W. D. de Vos
6. G. Clarke
7. S. Duncan
8. K. Scott

In Nutrition and Dietetics

1. H. Flint
2. P. Louis
3. S. Duncan
4. K. Scott
5. G. Holtrop
6. Pauline Young
7. Patrice D Cani
8. A. Belenguer

Citations in the corpus

• From the gut to the peripheral tissues: the multiple effects of butyrate (2010, positive): “…bacteria, leading to linear SCFA, CO 2 and H 2 , predominate in the proximal colon, while the majority of proteolytic bacteria, yielding branched SCFA, CO 2 , CH 4 , H 2 , phenols and amines, are mainly in the distal colon where fermentable carbohydrates are depleted on transit (22,23) .”
• Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils. (2011, background): “Rectal enemas containing SCFAs mixtures, or just butyrate, has been shown (in most of the studies) to improve clinical and inflammatory parameters in the treatment of patients with ulcerative colitis [9].”
• A review on replacing fish meal in aqua feeds using plant protein sources (2018, background): “Generally, organic acids offer energy for growth (Eisemann and Van Heugten, 2007; Topping and Clifon, 2001) [80, 82], immunity (Jongbloed et al., 2000; Øverland et al., 2000) [81, 25] and gut health (Hamer et al., 2008) [83].”
• Genes and Molecules of Lactobacilli Supporting Probiotic Action (2008, background): “As mentioned above, butyrate is a particularly important source of energy for the colonic mucosal cells, and it was suggested to be necessary for the maintenance of the colonic epithelium (100, 220).”
• Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes (2011, background): “Butyrate is known as an anti-inflammatory short chain fatty acid that contributes to colon health [31–33].”
• Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. (2011, positive): “The transport proteins involved are mono-carboxylate transporter isoform 1 (MCT1), which is coupled to a transmembrane H + -gradient, and SLC5A8, which is Na + -coupled co-transporter [3,4] .”
• Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut (2016, background): “Butyrate, in particular, is one of the preferred energy sources of the colonic epithelium (36).”
• The first 1000 cultured species of the human gastrointestinal microbiota (2014, background): “Butyrate can be used as an energy source by the gut epithelial cells, and it has anticarcinogenic and anti-inflammatory properties (Hamer et al., 2008).”
• Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data (2014, background): “Recently, butyrate gained attention, because of its proposed key role in maintaining gut homeostasis and epithelial integrity, since it serves as the main energy source for colonocytes, directly influences host gene expression by inhibiting histone deacetylases, and interferes with proinflammatory s”
• Colonic bacterial composition in Parkinson's disease (2015, background): “Short-chain fatty acids (SCFAs), especially butyrate-producing bacteria at the intestinal level, play a major regulatory role in the intestinal ecosystem to maintain gastrointestinal function and body health.(29-32) Please refer to the K E S H A V A R Z I A N E T A L”
• Essential oils and their use in animal feeds for monogastric animals - effects on feed quality, gut microbiota, growth performance and food safety: a review. (2018, background): “…2010; Tiihonen et al. 2010), the TC blend increased the proportion of SCFA butyrate in the caecum which is known to provide energy to colonic mucosa (Roediger 1980) and thus has potentially important implications for intestinal immunity (for a review see (Scheppach et al. 2001; Hamer et al. 2008)).”
• The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, background): “While concentrations in the portal vein are still considerable (~18μmol/l in a fasting human, 14-64μmol/l in sudden death victims (Cummings et al., 1987; Hamer et al., 2008; Peters et al., 1992), concentrations in peripheral blood appear to be relatively low (lower μ-molar range, ~20% of portal vein”