Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

By Jacobo de la Cuesta-Zuluaga, N. Mueller, V. Corrales-Agudelo, Eliana P. Velásquez-Mejía, J. Carmona, J. M. Abad, J. Escobar. Diabetes Care, 2016

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Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila (2017, background): “Conversely, antidiabetic treatments, such as metformin administration and bariatric surgery were both found to be associated with a marked increase in the abundance of A. muciniphila (Figure 1) (Shin et al., 2014; Forslund et al., 2015; de la Cuesta-Zuluaga et al., 2017).”
Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition. (2017, background): “These include the lactate-producing Lactobacillus salivarius (Messaoudi et al., 2013) and butyrate-producing Butyrivibrio (de la Cuesta-Zuluaga et al., 2017), Clostridium symbiosum (O’Keefe et al., 2015), and Eubacterium species (Vrieze et al., 2012; Udayappan et al., 2016).”