From the gut to the peripheral tissues: the multiple effects of butyrate
By P. Guilloteau, L. Martin, V. Eeckhaut, R. Ducatelle, R. Zabielski, F. Immerseel. Nutrition research reviews, 2010
750 citations recorded by the source corpus.
Butyrate is a natural substance present in biological liquids and tissues. The present paper aims to give an update on the biological role of butyrate in mammals, when it is naturally produced by the gastrointestinal microbiota or orally ingested as a feed additive. Recent data concerning butyrate production delivery as well as absorption by the colonocytes are reported. Butyrate cannot be detected in the peripheral blood, which indicates fast metabolism in the gut wall and/or in the liver. In physiological conditions, the increase in performance in animals could be explained by the increased nutrient digestibility, the stimulation of the digestive enzyme secretions, a modification of intestinal luminal microbiota and an improvement of the epithelial integrity and defence systems. In the digestive tract, butyrate can act directly (upper gastrointestinal tract or hindgut) or indirectly (small intestine) on tissue development and repair. Direct trophic effects have been demonstrated mainly by cell proliferation studies, indicating a faster renewal of necrotic areas. Indirect actions of butyrate are believed to involve the hormono–neuro–immuno system. Butyrate has also been implicated in down-regulation of bacteria virulence, both by direct effects on virulence gene expression and by acting on cell proliferation of the host cells. In animal production, butyrate is a helpful feed additive, especially when ingested soon after birth, as it enhances performance and controls gut health disorders caused by bacterial pathogens. Such effects could be considered for new applications in human nutrition.
Subfields: Food Science, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/4c19ce1d96d87ca78517770739d02c1f31481dcc
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Citations in the corpus
- Effect of dietary butyric acid on performance, intestinal morphology, microflora composition and intestinal recovery of heat-stressed broilers (2016, background): “Under natural growing environments of broilers, butyric acid was reported to increase villi growth and heights (Guilloteau et al., 2010; Levy et al., 2015) and control intestinal pathogenic bacteria (Namkung et al.”
- Effect of Partially Protected Sodium Butyrate on Performance, Digestive Organs, Intestinal Villi and E. coli Development in Broilers Chickens (2014, background): “…bacteria and improved performance, increased digestibility and reduced oxidative stress and inflammatory processes (Van Inmersel et al., 2004; Panda et al., 2009; Fernandez-Rubio et al., 2009; Guilloteau et al., 2010, Mallo et al., 2012), however there are still details to be clarified in poultry.”
- Butyrate: A Double-Edged Sword for Health? (2018, background): “A carrier-mediated, HCO3− gradient-dependent anionbutyrate exchange system is present on the basolateral membrane (5).”
- The effect of inulin on broiler chicken intestinal microflora, gut morphology, and performance (2012, background): “Butyrate has also been implicated in down-regulation of bacteria virulence, both by direct effects on virulence gene expression and by acting on cell proliferation of the host cells (Guilloteau et al., 2010).”