A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes

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Genetic variants of miRNA sequences and non-small cell lung cancer survival. (2008, positive): “The loss and gain of function of specific miRNAs were also thought to be key events in the genesis of diverse cancers (8, 9).”
MicroRNA control in the immune system: basic principles. (2009, background): “…of this Cell 136, January 9, 2009 ©2009 Elsevier Inc. 33 process, including tumor metastasis and cancer stem cell maintenance (Huang et al., 2008; Kent and Mendell, 2006; Ma et al., 2007; Tavazoie et al., 2008; Yu et al., 2007). miRNAs appear also to be heavily involved in the pathogenesis of…”
Regulation of the p27Kip1 tumor suppressor by miR‐221 and miR‐222 promotes cancer cell proliferation (2007, background): “Recently, research has uncovered both the tumor suppressive and oncogenic potential of a number of miRNAs, underscoring their importance in human cancer (Lu et al, 2005; He et al, 2005b; Calin and Croce, 2006; Esquela-Kerscher and Slack, 2006; Kent and Mendell, 2006; Mayr et al, 2007).”
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. (2008, background): “Several studies have confirmed that miRNAs regulate cell proliferation and apoptosis (2, 4, 5).”
The Structure of Human Argonaute-2 in Complex with miR-20a (2012, neutral): “This cluster is important for heart and lung development and for proper lymphoid differentiation (Kent and Mendell, 2006).”