Widespread microRNA repression by Myc contributes to tumorigenesis

By Tsung-Cheng Chang, Duonan Yu, Yun‐Sil Lee, Erik A. Wentzel, Dan E. Arking, K. West, C. V. Dang, A. Thomas-Tikhonenko, Joshua T. Mendell. Nature Genetics, 2008

1,395 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/186726f1abb658403ddc90ed784f3c495a766a78

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Citations in the corpus

MYC on the Path to Cancer (2012, background): “Another critical mode for Myc-mediated gene repression is through its ability to activate microRNAs (miRNAs) (Figure 3) (Chang et al., 2008; O’Donnell et al., 2005).”
Double-hit B-cell lymphomas. (2011, neutral): “Johnson et al15 2009 54/54 (100) 20/54 (46) 62 (24-93) 41/54 (76) 27/54 (50) 32/45 (71)§ NA 19/54 (35) 38/54 (70)”
Myc and cell cycle control. (2015, background): “targeted by let-7 miRNAs include Cdc25a, Cdk6, cyclin A, cyclin D1 D2 and D3 [126–128].”
MicroRNA (miRNA) in cancer (2015, background): “The principal effect of Myc activation was the repressed expression of multiple miRNA [56,57] as well as down-regulation of several anti-proliferative, pro-apoptotic and tumor suppressor effects such as let-7, miR15a/16-1, miRNA-26a and miR-34 family members [58].”
A novel and universal method for microRNA RT-qPCR data normalization (2009, background): “5-fold difference, can have a significant impact on the biology of the cell [27-32].”
Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “Indeed, recent data demonstrated that the transcription factor Myc can activate or repress different sets of miRNAs.(52)”
MicroRNAs and cancer: short RNAs go a long way. (2009, background): “Finally, widespread transcriptional silencing of miRNAs by c-Myc (Chang et al., 2008) has been reported, suggesting a potential mechanism for the observed global downregulation of miRNAs in transformed cells.”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “, 2006), and a high level of c-Myc also leads to a decrease of multiple miRNAs known to have anti-tumorigenic properties (Chang et al., 2008).”
An Analysis of Human MicroRNA and Disease Associations (2008, result): “In the new dataset, miR-195 was reported to be down regulated in human B cell lymphomas[23], which is also consistent with the previous results.”
MicroRNAs: new regulators of immune cell development and function (2008, background): “, whereas the proto-oncogene product c-Myc might be involved in the transcriptional repression of the miR-146a locus during tumorigenesi”
MYC, metabolism, cell growth, and tumorigenesis. (2013, background): “It appears that MYC could also transcriptionally increase GLS mRNA levels in other systems (Wise et al. 2008; Gao et al. 2009).”
Therapeutic delivery of miR-26a inhibits cancer cell proliferation and induces tumor-specific apoptosis (2009, background): “We previously demonstrated that Myc activation in B cell lymphoma models results in downregulation of a large cohort of miRNAs, including miR-15a/16, miR-26a, miR-34a, miR-150, and miR-195 (Chang et al., 2008).”
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis (2010, background): “MYC directly regulates the expression of a diverse set of miRNAs (for example the oncogenic miR-17-92 cluster) that contribute to tumorigenesi”
MicroRNA and cancer (2012, background): “Tumours often present reduced levels of mature miRNAs (Lu et al., 2005) as a consequence of genetic loss, epigenetic silencing, defects in their biogenesis pathway or widespread transcriptional repression as documented for MYC (Chang et al., 2008) (Figure 1A).”