The SCF ubiquitin ligase: insights into a molecular machine

By Timothy Cardozo, M. Pagano. Nature reviews. Molecular cell biology, 2004

1,158 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/38ea289c966bf4d856e0c04696776746c8d67823

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Citations in the corpus

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition (2007, background): “Once active, Cdk2 also triggers the degradation of p27 through the SCFSkp2 ubiquitin ligase (Cardozo and Pagano, 2004).”
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer (2008, background): “The SCF ubiquitin ligases are the most characterized mammalian CRL”
DNA damage checkpoints: from initiation to recovery or adaptation. (2007, background): “The explanation for how one enzyme can control the opposing processes of checkpoint initiation and recovery lies in the basic principles of the SCF–substrate interaction, which is strictly phosphorylation-dependent [44].”
Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1 (2006, background): “The model structure of the Skp1-Cul1-F-box protein (SCF) E3 ligase complex provides excellent insights into this hypothesis (3, 31, 47).”
Structure and function of WD40 domain proteins (2011, background): “SCF ubiquitin ligase mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription ( Cardozo and Pagano, 2004 ).”
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, positive): “The members of the SCF family of E3 ubiquitin ligases each consist of the adapter protein Skp1, the scaffold protein Cul1, the RING box protein RBX1 (also called ROC1 or HRT1), and an F-box substrate receptor protein that varies depending on the substrate to be ubiquitinated [290, 291].”
The age of crosstalk: phosphorylation, ubiquitination, and beyond. (2007, background): “The majority of Ser/Thr phosphorylation-dependent ubiquitination targets are recognized by members of the SCF family of E3 ligases, which contain a Skp1/cullin core associated with the Rbx1 RING finger protein, and an F box protein, which acts as a substrate specificity determinant ( Cardozo and Pag”
Systematic analysis and nomenclature of mammalian F-box proteins. (2004, background): “Interestingly, SKP2 is the product of a proto-oncogene, FBW7 is a tumor suppressor (Pagano and Benmaamar 2003; Yamasaki and Pagano 2004), and overexpression of -TRCP1 can contribute to transformation at least in some epithelial tissues GENES & DEVELOPMENT 2577 (Kudo et al. 2004).”