The age of crosstalk: phosphorylation, ubiquitination, and beyond.

By T. Hunter. Molecules and Cells, 2007

970 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/56deaaf67230458f93a824bd7a3c2ffaac12f9e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. D. Komander
2. Matthias Mann
3. Chunaram Choudhary
4. Jüergen Cox

In Molecular Biology

1. Matthias Mann
2. Jüergen Cox
3. Stefka Tyanova
4. Chunaram Choudhary
5. John R. Yates III
6. C. Ruse
7. A. Nakorchevsky
8. D. Komander

Citations in the corpus

• Quantitative proteomics reveal a feed-forward model for mitochondrial PARKIN translocation and UB chain synthesis (2014, positive): “Protein phosphorylation and ubiquitin (UB) systems function hand in hand to control signaling networks (Hunter, 2007).”
• Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis (2018, background): “Normal human development is tightly controlled by complex signaling pathways, which allow cells to communicate with each other and their surrounding environment.(72,73) Not surprisingly, many of these same signaling pathways are dysregulated or hijacked by cancer cells and CSCs.”
• Decoding signalling networks by mass spectrometry-based proteomics (2010, background): “Note that different signalling activators initiate multiple signalling pathways and share some of the same components, which is known as signalling crosstal”
• Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. (2014, background): “Phosphorylated Residues Are Preferentially Located near Modifiable Lysines Crosstalk between different types of posttranslational modification is an emerging theme in signaling biology (Hunter, 2007).”
• The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) (2017, neutral): “Sometimes, protein phosphorylation may promote the formation or removal of a second PTM (4,57) (Fig.”
• Proteomics by mass spectrometry: approaches, advances, and applications. (2009, background): “For example, two or more modifications can directly compete for the same single residue in a negative cross talk (230).”
• Breaking the chains: structure and function of the deubiquitinases (2009, background): “There is extensive crosstalk between phospho and ubiquitin signalling network”
• Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “Phosphorylation can regulate the ubiquitination of a protein in different ways, such as promoting recognition by an E3 ligase via conformational change or regulating substrate and ligase interactions at the level of subcellular compartmentalization (Hunter, 2007).”