Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
By David Frescas, M. Pagano. Nature Reviews. Cancer, 2008
961 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/94ff704d820b96f4557359ac5f386100895334a8
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Citations in the corpus
- Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials (2020, background): “The aberrant UPS system is responsible for the occurrence of various diseases.(165,166) UPS consists of ubiquitin-activating enzyme 1 (E1), ubiquitin-conjugating enzyme 2 (E2), ubiquitin-protein ligase 3 (E3) and proteasome.”
- Targeting the ubiquitin system in cancer therapy (2009, background): “For example, SCF-β–TrCP recognizes two well defined interspaced phosphorylated serine residues (DS 52 GXXS 56 ) in substrates such as β-catenin and IκBα, whereas SCF–Skp2 recognizes a phosphorylated threonine residue in p27 Kip1 (ref”
- A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). (2010, background): “In the reported phosphodegron variants, some of them require the second serine to be further away from the DSG (Frescas and Pagano 2008), and, in certain cases like CDC25A, the second S is not even required (Jin et al.”
- Therapy-induced senescence in cancer. (2010, background): “In cancer, the downregulation of p27Kip1 and expression of its regulator ubiquitin ligase SKP2 has been identified in prostate and other cancers (92,93), as well as in precancerous lesions (17).”
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. (2012, background): “Through creating a phosphodegron in Nrf2 that is recognized by SCFβ-TrCP, it seems that GSK-3 provides a pivotal control hub by which the CNC-bZIP factor can be both up- and down-regulated.”
- HECT and RING finger families of E3 ubiquitin ligases at a glance (2012, background): “SCFb-TrCP is also responsible for the degradation of EMI1 in late G2 phase (Frescas and Pagano, 2008).”
- NF‐κB and the link between inflammation and cancer (2012, background): “b-TrCP has been shown to impact a broad swath of NF-jB signaling (185).”