Role of extracellular matrix assembly in interstitial transport in solid tumors.

By Paolo Antonio Netti, D. Berk, M. Swartz, Alan J. Grodzinsky, Rakesh K. Jain. Cancer Research, 2000

1,168 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/384f88e0fccc50826b49bc24b921f66c44e23740

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Citations in the corpus

Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. (2013, background): “The extracellular matrix produced by the activated fibroblast is a barrier to convective and diffusive transport, and this is particularly significant for nanoparticles compared to small molecules [106, 108, 109].”
Extracellular matrix (ECM) stiffness and degradation as cancer drivers (2018, background): “ECM is one of the sources of physiologic resistance of cancer cells to treatment, and it is considered to be a serious flaw of anti‐cancer approaches such as gene and immune therapies.(26) ECM stiffness is obstructive for effective uptake or delivery of drugs to the intratumoral area.”
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “IIID), in turn influencing the uptake of therapeutic agents (104, 323, 365).”
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation (2003, background): “jpg" NDATA ITEM> ]> Collagen content and structure are key determinants of macromolecular transport in tumor”
Nanomedicine therapeutic approaches to overcome cancer drug resistance (2013, background): “Tumors with a well-organized collagen network prevent some high-molecular weight drugs from penetrating when compared to a poorly organized collagen structure [68].”
The role of mechanical forces in tumor growth and therapy (2014, unknown): “Therefore, tumors rich in collagen might exhibit an order of magnitude lower hydraulic conductivity than those of low collagen content tumors (86).”
Dissecting tumour pathophysiology using intravital microscopy (2002, background): “These studies have shown that diffusive transport of macromolecules is slower in tumours than in water, and that it decreases with molecular weight and binding affinit”
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors (2011, background): “Arafat HA, et al. (2007) Antihypertensives as novel antineoplastics: Angiotensin-Iconverting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma.”
Tensional homeostasis and the malignant phenotype. (2005, background): “Tumor rigidity could influence treatment efficacy (Netti et al., 2000) and may enhance tumor metastasis (Akiri et al., 2003).”
Drug penetration in solid tumours (2006, background): “Finally, the composition and structure of the extracellular matrix (ECM) can slow down the movement of molecules within the tumou”
Delivering nanomedicine to solid tumors (2010, background): “The collagen content is the major determinant of interstitial transport ( Figure 3c )”