Tensional homeostasis and the malignant phenotype.

By Matthew J. Paszek, Nastaran Zahir, Kandice R Johnson, J. Lakins, G. Rozenberg, A. Gefen, Cynthia A. Reinhart-King, S. Margulies, Micah Dembo, D. Boettiger and 2 more. Cancer Cell, 2005

3,966 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/51e2df279f90fcbb096e16ba5b7f6f3546003549

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Citations in the corpus

The role of mechanical forces in tumor growth and therapy (2014, positive): “Stiffening of the matrix and the resulting increase of the stress levels can in turn induce production of fibronectin, enhance focal adhesions, and increase cytoskeletal tension by Rho/Rock signaling activation (33, 34).”
Cellular mechanotransduction: putting all the pieces together again (2006, background): “Cells also alter the concentration of forces they exert on the ECM to maintain tensional homeostasis that is necessary for the preservation and regeneration of normal functional tissue architecture (135, 142, 143), and disruption of this force balance may contribute to cancer formation (144, 145).”
Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells (2009, methodology): “, 2007a, 2007b), which allowed us to physiologically model the dimensionality and stiffness of in vivo mammary tumor microenvironments (Paszek et al., 2005).”
Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “Increased deposition of matrix pr teins promotes tumour progression by int rfering with cell–cell adhesion, cell polarity, and ultimately amplifying growth factor signalling [133].”
Review on Cell Mechanics: Experimental and Modeling Approaches (2013, background): “Many pathological diseases, such as asthma [5], osteoporosis [6], deafness [7], atherosclerosis [8], cancer [9], osteoarthritis [10], glaucoma [11], and muscular dystrophy [12] can be directly caused by or catalyzed by irregular cellular or tissue mechanics [4].”
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “When breast cancer cells are placed in a rigid 3D matrix, Rho signaling and integrinmediated mechanotransduction, acting in a feedforward positive reinforcement cycle, drive disruption of epithelial adhesion and polarity and induce invasion (Paszek et al., 2005).”
Physical traits of cancer (2020, background): “Today, there are numerous studies showing how thematerial properties—in particular, the stiffness of themicroenvironment—are central to many traits of cancer (79), including proliferation (80, 81), angiogenesis (82), metabolism (83), invasion (84–86), andmigration andmetastasis (87–89) (Fig.”
Integrins and extracellular matrix in mechanotransduction. (2010, background): “Matrix stiffness and cytoskeletal stress are functionally linked through key signaling proteins during tumorigenesis which cooperate to drive focal adhesion assembly, contributing to a rigid tumor microenvironment.(95) Conclusion Cell–matrix interactions are essential for maintaining the integrity o”
Cancer metastasis: building a framework. (2006, background): “For example, tensional forces on mammary epithelial cells during tumorigenesis may result in clustering of mechanotransducing integrins and subsequent downstream activation of ERK and Rho-GTPase (Paszek et al., 2005).”