The role of mechanical forces in tumor growth and therapy
By Rakesh K. Jain, John D. Martin, Triantafyllos Stylianopoulos. Annual Review of Biomedical Engineering, 2014
956 citations recorded by the source corpus.
Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase their invasive and metastatic potential. Tumor vessels - while nourishing the tumor - are usually leaky and tortuous, which further decreases perfusion. Hypo-perfusion and hypoxia contribute to immune-evasion, promote malignant progression and metastasis, and reduce the efficacy of a number of therapies, including radiation. In parallel, vessel leakiness together with vessel compression cause a uniformly elevated interstitial fluid pressure that hinders delivery of blood-borne therapeutic agents, lowering the efficacy of chemo- and nano-therapies. In addition, shear stresses exerted by flowing blood and interstitial fluid modulate the behavior of cancer and a variety of host cells. Taming these physical forces can improve therapeutic outcomes in many cancers.
Subfields: Biomedical Engineering, Cell Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/c71efa0cd96a4edb99b7e0a31afeb20465d4b2e1
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Citations in the corpus
- Tumor angiogenesis and vascular normalization: alternative therapeutic targets (2017, background): “In addition, compressive stress inhibits lymphatic network functionality and hinders the drainage of excessive interstitial fluid [43].”
- ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, neutral): “Although our understanding of the biochemical crosstalk between the stroma and cancer cells has grown exponentially, our understanding of the physical microenvironment is in its early stages (Jain et al., 2014).”