Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

By B. Diop-Frimpong, Vikash P Chauhan, S. Krane, Y. Boucher, Rakesh K. Jain. Proceedings of the National Academy of Sciences of the United States of America, 2011

694 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9b1c47c4c339363b6015a9acf2f99c4ad62d642b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Rakesh K. Jain
2. Triantafyllos Stylianopoulos
3. Y. Barenholz
4. John D. Martin
5. Lance L. Munn
6. Jun Wu
7. Vikash P Chauhan
8. Y. Boucher

In Immunology and Allergy

1. Y. Barenholz
2. Rakesh K. Jain
3. Triantafyllos Stylianopoulos
4. Lance L. Munn
5. Y. Boucher
6. O. Farokhzad
7. N. Bertrand
8. John D. Martin

In Molecular Biology

1. Rakesh K. Jain
2. Triantafyllos Stylianopoulos
3. Y. Barenholz
4. John D. Martin
5. O. Farokhzad
6. N. Bertrand
7. Lance L. Munn
8. Jun Wu

Citations in the corpus

• Challenges and strategies in anti-cancer nanomedicine development: An industry perspective. (2017, background): “[89–90], from degradation of collagen [91] or inhibition of its synthesis [92] or cross-linking [93], and from vascular normalisation [94].”
• Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors (2012, background): “Antisolid stress approaches could also be combined with tumor-targeting ligands (65) and matrix-modifying agents (52) to improve drug delivery and efficacy.”
• Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels (2013, neutral): “Deleterious effects on blood pressure may contraindicate angiotensin inhibitors for some patients 14,54 .”
• Doxil®--the first FDA-approved nano-drug: lessons learned. (2012, methodology): “A very promising approach is the one used recently by Jain and coworkers [122].”
• Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, methodology): “In a similar fashion, other methods remodelling the perivascular environment have been exploited using photo-immunotherapy [66] or small molecular weight drugs [67].”
• Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. (2013, background): “Data adapted.(143) HSV, herpes simplex virus.”
• Targeting Tumor Microenvironment for Cancer Therapy (2019, background): “The inhibition of the transforming growth factor-β (TGF-β) signaling pathway mediated by Losartan and its analogs results in a reduced secretion of collagen I and consequently reduced desmoplasia, improving the delivery of chemotherapeutics to tumor cells [28,29].”
• Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “Doxil) was increased upon losartan cotreatment through the suppression of collagen I synthesis [78].”
• The role of mechanical forces in tumor growth and therapy (2014, positive): “This in turn, alleviates solid stress levels and improves tumor perfusion as well as the delivery of both chemotherapeutic agents and nanomedicines, and thereby increasing the overall survival of mice bearing tumors (135, 136).”