Drug penetration in solid tumours

By A. Minchinton, I. Tannock. Nature Reviews. Cancer, 2006

2,678 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b36f0133fd5f4b28eafc9812ef163da2c5df61f9

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In Biomaterials

In Oncology

Citations in the corpus

Multistage nanoparticle delivery system for deep penetration into tumor tissue (2011, background): “Surface PEGylation of the small nanoparticles allows them to diffuse smoothly in the interstitial matrix by reducing the binding, sequestration, and metabolism that hinder the transport of therapeutic agents (21, 22).”
Continuous representation of tumor microvessel density and detection of angiogenic hotspots in histological whole-slide images (2015, positive): “Most models of cell metabolism, immune response and drug distribution are dependent on the pattern of tumor vascularization [38].”
Polymers for Drug Delivery Systems (2010, background): “However, recent studies have shown that tumor targeting may not be able to be achieved exclusively by the EPR effect owing to difficulties in reaching cancer cells deep inside malignant tissues (86), which underscores the need for synergistic passive and active targeting strategies.”
A tense situation: forcing tumour progression (2009, background): “Tumour-associated changes in interstitial pressure and compressive stress also present real challenges for the treatment of solid tumours with chemotherapeutic drug”
Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “The rate of diffusion through the tumor tissue is also affected by the properties of drugs (e.g., molecular weight, shape, charge, and solubility), by uptake in cancer or stromal cells, and by binding to the ECM (Figure 5A) (Minchinton and Tannock, 2006).”