Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation

By E. Brown, T. McKee, E. Ditomaso, A. Pluen, Brian Seed, Y. Boucher, Rakesh K. Jain. Nature Medicine, 2003

868 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a0536d2424d9c3e4387fec4fc8225090af497e82

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Citations in the corpus

Dynamic interplay between the collagen scaffold and tumor evolution (2010, background): “To address these concerns, second harmonic generation using two-photon microscopy has been used in live animals to monitor how epithelial and stromal cells interact with and initiate collagen remodeling to regulate its architecture [36,39,49,78,89,101].”
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer (2011, methodology): “Similarly, these techniques have been used to monitor the interactions of epithelial and stromal cells with tumors, as well as the initiation of collagen remodeling (Brown et al., 2003; Condeelis and Segall, 2003; Perentes et al., 2009; Wolf et al., 2009).”
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors (2011, methodology): “Based on our previous studies on the tumor interstitial matrix (6, 8), we hypothesized that a decrease in collagen content would improve the intratumoral distribution of nanoparticles.”
Delivering nanomedicine to solid tumors (2010, background): “The hormone relaxin, which modifies the structure of collagen fibers, can also increase transport by diffusion ( Figure 5b )”
Collagen reorganization at the tumor-stromal interface facilitates local invasion (2006, result): “Therefore, in an approach opposite to that taken by Jain and co-workers [39] where a decrease in collagen in vivo was detected with SHG, we detected increased collagen in live intact mammary glands.”
Interpreting second-harmonic generation images of collagen I fibrils. (2005, methodology): “Because SHG microscopy can be accomplished in vivo (Wang et al., 2002; Brown et al., 2003; Larson et al., 2003; Flesken-Nikitin et al., 2004), the technique exhibits promise for biomedical assessment of tissue structure, especially in processes where the extracellular matrix is being actively…”
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. (2013, background): “collagen matrix in a desmoplastic tumor and increased the penetration of large molecules (Data Supplement Fig S17).(145,146) Although we”
Illuminating the metastatic process (2007, background): “Treatment of mice with the hormone relaxin reduced the amount of fibrous collagen surrounding tumours and improved diffusive transpor”
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited (2009, background): “Barriers to cell migration: prevailing theories After neoplastic transformation, cancer cells infiltrate local tissues and initiate metastatic programs by trafficking through a stromal extracellular matrix (ECM) dominated by cross-linked networks of type I collagen, the major extracellular protein f”