Dissecting tumour pathophysiology using intravital microscopy

By Rakesh K. Jain, Lance L. Munn, Dai Fukumura. Nature Reviews. Cancer, 2002

618 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3632582ae5ae0861572a7d66360530e122ee3c2f

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Citations in the corpus

Angiogenesis in brain tumours (2007, background): “The vascular permeability of different tumours growing intracranially in mice is generally elevated, although it varies from one tumour to another, from one location in a tumour to another, and even from one day to anothe”
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. (2013, background): “tumor progression and in response to treatment (Data Supplement Fig S1).(10,11)”
Fundamentals of cancer metabolism (2016, background): “A salient feature of many tumors is that they reside in a low-oxygen environment (hypoxia) ranging from 0 to 2%O2 because the tumor cell proliferation rate often exceeds the rate of new blood vessel formation (angiogenesis) (22).”
Intravital imaging of cell movement in tumours (2003, methodology): “Intravital-imaging studies have been especially useful for characterizing primary-tumour properties, growth rates and mechanisms of metastasis to target organ”
Deep tissue two-photon microscopy (2005, methodology): “Moreover, 2PLSM is used as a tool to study the development, progression and potential treatment of pathological conditions such as tumor”
Fractal and multifractal analysis: A review (2009, methodology): “Indeed, fractal geometry was used to characterize and quantify the response for cancer treatment (Imre and Bogaert, 2004; Jain et al., 2002; Wax et al., 2003).”
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, positive): “Pioneering studies have established intravital imaging techniques for analyzing cell dynamics within the tissues of live mice, including within tumors (Brown et al., 2001; Jain et al., 2002; Brown et al., 2003; Halin et al., 2005; Hoffman, 2005; Stroh et al., 2005; Dreher et al., 2006; Sidani et al.”
Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers. (2009, background): “Previous preclinical and clinical studies have shown that functional and structural features of drug carriers should be optimized simultaneously in order to overcome the tissue penetration issue [53].”
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. (2007, background): “Regulation of angiogenesis and vessel functions by organ microenvironment Angiogenesis and functions of resultant vessels differ significantly between the same tumors grown in different host organs (Fidler, 2001; Jain et al., 2002).”
Cellular abnormalities of blood vessels as targets in cancer. (2005, background): “This abnormality results in leakiness [11], which, together with few or no functional lymphatic vessels and perhaps contractile stromal elements, increases interstitial fluid pressure [12].”
Imaging of angiogenesis: from microscope to clinic (2003, background): “Tumors implanted in transparent chambers in skin and other sites can be imaged over time by fluorescence microscop”
Consensus guidelines for the use and interpretation of angiogenesis assays (2018, background): “, albumin or high-molecular weight dextran) that are widely used in intravital microscopy techniques for measuring vascular permeability in vivo [230, 231].”