Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.

By F. Arai, A. Hirao, M. Ohmura, Hidetaka Sato, S. Matsuoka, K. Takubo, Keisuke Ito, G. Koh, T. Suda. Cell, 2004

2,042 citations recorded by the source corpus.

Subfields: Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/380e382f0806530a71461204d64cc49d7a711480

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In Hematology

1. S. Morrison
2. G. Semenza
3. P. Frenette
4. Linheng Li
5. A. Wagers
6. T. Suda
7. Irving L. Weissman
8. A. Trumpp

In Oncology

1. S. Morrison
2. Linheng Li
3. Irving L. Weissman
4. A. Wagers
5. A. Spradling
6. P. Bonaldo
7. F. Gattazzo
8. A. Urciuolo

Citations in the corpus

• Molecular regulation of angiogenesis and lymphangiogenesis (2007, background): “Further biological roles of the angiopoietins include the regulation of EC migration, endothelial tube formation, tumour angiogenesis, haematopoiesi”
• Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2 mediated regeneration of sinusoidal endothelial cells (2009, positive): “Although the phenotypic and functional attributes of the OBN are well defined (Arai et al., 2004; Calvi et al., 2003; Hattori et al., 2002; Heissig et al., 2002; Kiel et al., 2005; Yoshihara et al., 2007; Zhang et al., 2003), the identity of the vascular compartments in BM contributing to…”
• Stem cell niche: structure and function. (2005, background): “In addition, N-cadherin is a key target of Angiopoietin-1 (Ang-1)/Tie-2 signaling that maintains HSC quiescence (Arai et al. 2004) (Figure 4).”
• Osteoimmunology: interplay between the immune system and bone metabolism. (2006, background): “This signaling system inhibits cell division in HSCs while maintaining their capacity for self-renewal (20).”
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Angiopoietin-1, a factor proposed to regulate HSC quiescence (Arai et al., 2004), is another example.”
• No place like home: anatomy and function of the stem cell niche (2008, background): “Similarly, even in the adult blood system, multiple niches for HSCs may exist (including osteoblastic, vascular and perhaps others) and might provide distinct regulatory functions to balance self-renewa”
• A Neurovascular Niche for Neurogenesis after Stroke (2006, background): “…niche Ang1 and SDF1 are expressed by endothelial cells, upregulated by hypoxia after stroke, and directly regulate stem cell differentiation or migration through their receptors Tie2 and CXCR4 (Jones et al., 2001; Stumm et al., 2002; Arai et al., 2004; Imitola et al., 2004; Robin et al., 2006).”
• Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. (2005, background): “It is not clear whether EPCs originate in the BM from primitive (hemo)angioblasts and are immature R INC. DOI 10.1016/j.ccr.2005.08.002 211 cells possibly related to hematopoietic stem cells (HSCs), rather than differentiating from lineage-committed HCs, such as monocytes, which can acquire an EC-li”
• Normal stem cells and cancer stem cells: the niche matters. (2006, background): “In adults, hematopoiesis occurs in bone marrow in which hematopoietic stem cells (HSC) are primarily located in the osteoblastic niche on the bone surface (21, 22 , 26, 27).”
• Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. (2007, background): “Reported to be produced by osteoblasts, Ang-1 has also been implicated as a key component of the HSC niche in postnatal murine bone (Arai et al., 2004).”