Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms.

By D. Prockop. Molecular Therapy, 2009

596 citations recorded by the source corpus.

Research on stem cells has progressed at a rapid pace and, as might be anticipated, the results have generated several controversies, a few myths and a change in a major paradigm. Some of these issues will be reviewed in this study with special emphasis on how they can be applied to the adult stem/progenitor cells from bone marrow, referred to as MSCs.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/ff54ac899807d450a741b4f05afef3d1fe7c7921

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Citations in the corpus

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype (2010, background): “owing to their lack of host immune reactivity [2].”
Mechanisms of mesenchymal stem/stromal cell function (2016, background): “Still largely unsolved, the mystery of efficacy without long-term engraftment, especially in non-mesodermal tissues, remains a source of considerable debate [24, 25].”
Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, unknown): “Most likely, the ‘‘true’’ stem cells constitute only a subset of the bone marrow cell population, as selected by rapid plastic adherence, implying that this cell population is heterogeneously composed of bona fide stem cells, their progeny (with multilineage differentiation potential, but without sa”