Control of stem cell fate by physical interactions with the extracellular matrix

By F. Guilak, Daniel M. Cohen, B. Estes, Jeffrey M. Gimble, W. Liedtke, Christopher S. Chen. Cell Stem Cell, 2009

1,855 citations recorded by the source corpus.

A diverse array of environmental factors contribute to the overall control of stem cell activity. In particular, new data continues to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.

Subfields: Biomedical Engineering, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/77ba681f6d16e5408f8dea48a9cfd4ef045c026b

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Citations in the corpus

Alginate: properties and biomedical applications (2012, background): “It has been demonstrated that chondrogenic lineage of adult stem cells could be regulated via the introduction of soluble factors and biophysical cues in 3D cell culture systems [180].”
Engineering microfluidic concentration gradient generators for biological applications (2013, neutral): “…been tuned to contain multiple chemical species (Keenan, Hsu et al. 2006; Hamid, Blencowe et al. 2010; Suri and Schmidt 2010) and biophysical cues (Guilak, Cohen et al. 2009; Tripathi, Kathuria et al. 2009; Connelly, Gautrot et al. 2010; Kilian, Bugarija et al. 2010), thereby mimicking the…”
Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells (2009, background): “Taken together, the observations of nanotopography-induced and stiffness-directed differentiation suggest that physical interactions between the cells and the extracellular environment, either in the form of topography or stiffness, or the combination thereof, can modulate cell function and stem cel”
Engineering microscale topographies to control the cell–substrate interface (2012, background): “There has been a remarkable growth in using embryonic and adult stem cells in tissue engineering given their self-renewal and differentiation capacities [140-143].”
A review on the progress of polymer nanostructures with modulated morphologies and properties, using nanoporous AAO templates (2016, background): “The interactions between the cells and the topographically different substrates lead to specific cell responses and result in different cell functions[234, 235].”
Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “As discussed above, one mechanism by which the ECM niche influences stem cell fate is through the realization of a bulk stiffness [88].”
Nanotopography-guided tissue engineering and regenerative medicine (2012, background): “of focal adhesions and (ii) the modulation of effective modulus or protein adsorption [95].”