Dendritic-cell trafficking to lymph nodes through lymphatic vessels

By G. Randolph, V. Angeli, M. Swartz. Nature reviews. Immunology, 2005

1,171 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/373bbd7cf9b298553eaaf434d8d682e8de9c4b14

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. H. Hemmi
2. A. Manfredi
3. Miriam Merad
4. J. Villadangos
5. Nir Yosef
6. M. Bianchi
7. R. Steinman
8. M. Swartz

In Oncology

1. H. Wiig
2. G. Randolph
3. V. Angeli
4. J. Hubbell
5. M. Swartz

Citations in the corpus

• High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity (2007, background): “Immature DCs are CCL5-sensitive, whereas mature DCs switch to CCL21 sensitivity and have an improved ability to migrate to secondary lymph nodes (65).”
• Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation (2014, neutral): “T cells (Randolph et al., 2005).”
• Cross-tissue immune cell analysis reveals tissue-specific features in humans (2022, background): “CCR7 is upregulated in tissue DCs following TLR or FcγR ligation (35, 36), enabling migration towards CCL19/21-expressing lymphatic endothelium and stromal cells in the T cell zone of lymph nodes (37, 38).”
• Exploiting lymphatic transport and complement activation in nanoparticle vaccines (2007, background): “, where dendritic cells reside in much lower numbers and must travel to the lymph node after antigen uptak”
• Dendritic cells: translating innate to adaptive immunity. (2006, background): “The migration of DCs has recently been reviewed [33].”
• Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “Lymph nodes are organized in clusters throughout the lymphatic system and are compartmentalized with narrow fluid crevices where the vascular compartment opposes each lymph compartment for fluid exchange and cell transport (375, 448).”
• The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “Nonlymphoid tissue cDCs constantly migrate through afferent lymphatics to the T cell areas of LNs charged with antigens (44) in the steady state, and this process increases manyfold in response to inflammatory signals (reviewed in 44, 47, 48).”
• Lymphoid organ development: from ontogeny to neogenesis (2006, background): “Lymphocytes enter the lymph node by extravasation across HEVs; soluble antigen and DCs enter via afferent lymphatic vessels at multiple sites along the capsul”
• Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo (2007, background): “The first category corresponds to the migratory DCs, which develop from earlier precursors in peripheral tissues and travel through the afferent lymphatics to reach the local draining lymph node”