Exploiting lymphatic transport and complement activation in nanoparticle vaccines

By Sai T. Reddy, A. J. Vlies, E. Simeoni, V. Angeli, G. Randolph, C. O'neil, Leslie K Lee, M. Swartz, J. Hubbell. Nature Biotechnology, 2007

1,251 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5456b3b65d9ac37a23ec8b32d27618dadff7bc8a

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Citations in the corpus

Impact of nanotechnology on drug delivery. (2009, background): “Similarly, in the case of immunological tissue targeting, such as targeted drug delivery systems as vaccine where particles are transported through the lymphatic vessels to draining lymph nodes, size-mediated targeting has been shown to be important for efficient antigen presentation to cells in the”
Bio-inspired, bioengineered and biomimetic drug delivery carriers (2011, background): “By mimicking this size-dependent transport process, synthetic polymer particles that carry antigens and are”
Designer vaccine nanodiscs for personalized cancer immunotherapy (2016, neutral): “To address these issues, various nano-vaccine systems have been evaluated in animal models with varying degrees of success 5-15 .”
Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures (2017, background): “This is for example the case for cardiovascular diseases or immunological tissue targeting where ligand-mediated targeting is important for efficient antigen presentation to cells in the lymph nodes as well as for efficient cell uptake [41,43].”
Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction (2012, background): “Unlike other conventional adjuvants, such as Montanide (incomplete Freund’s adjuvant) and alum (aluminum hydroxide), which have both been traditionally suggested to aid in antigen depot and release (11), the MPLA danger signal may be more appropriate in the context of a malaria vaccine because TLR4 ”