SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

By Jay D. Horton, J. Goldstein, Michael S. Brown. Journal of Clinical Investigation, 2002

5,004 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/372d3cce29164a00b160222fcbeacb084e621ffa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. David M. Sabatini
2. M. Laplante
3. B. Manning
4. J. Y. Chiang
5. J. Goldstein
6. Michael S. Brown
7. Craig B. Thompson
8. Jiajun Zhu

In Oncology

1. J. Y. Chiang
2. J. Goldstein
3. Michael S. Brown
4. David M. Sabatini
5. Tiangang Li
6. Shijie Li
7. F. Maxfield
8. S. Piccolo

In Surgery

1. J. Y. Chiang
2. David M. Sabatini
3. G. Hotamışlıgil
4. J. Goldstein
5. Michael S. Brown
6. I. Tabas
7. M. Laplante
8. Chunming Cheng

Citations in the corpus

• Role of cholesterol and lipid organization in disease (2005, background): “The SREBP family of transcriptional regulators has significant effects on levels of proteins involved in fatty-acid synthesis and modification in addition to their effects on cholesterol synthesi”
• Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression (2015, background): “SREBPs activate the genes encoding nearly every key enzyme in both the fatty acid and sterol biosynthetic pathways [102].”
• Characterization and modulation of gene expression and enzymatic activity of delta-6 desaturase in teleosts: A review (2011, background): “In humans, SREBP-1c would induce Δ6D gene transcription binding to SRE (Sterol Regulatory Element), a promoter region located on the Δ6D gene (Horton et al., 2002; Matsuzaka et al., 2002).”
• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “SREBP-1c induces the expression of a number of genes involved in de novo lipogenesis including acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), acetyl-CoA synthetase, ATP-citrate lyase, malic enzyme, glucose-6-phosphate dehydrogenase, 6phosphogluconate dehydrogenase, and stearoyl-CoA desatur”
• The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. (2005, background): “SREBPs are involved in fatty acid biosynthesis and triglyceride metabolism (Horton et al., 2002).”
• Bile Acid Metabolism and Signaling (2013, neutral): “When intracellular oxysterol levels decrease, a basic helix-loop-helix-leucine zipper protein called steroid response element binding protein-2 (SREBP-2) precursor (125 kDa) is dissociated from insulin induced gene-1 (Insig-1) and Insig-2 in the endoplasmic reticulum membrane and is escorted by a st”
• Lipid metabolism reprogramming and its potential targets in cancer (2018, background): “EGFR/EGFRvIII promotes lipid synthesis by activating SREBP-1 via PI3K/Akt signaling [12, 34, 87].”
• Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, background): “There are three SREBP isoforms, designated SREBP-1a, SREBP-1c, and SREBP-2 [ 138 ].”