Role of cholesterol and lipid organization in disease

By F. Maxfield, I. Tabas. Nature, 2005

1,279 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/d79e8fdd4335c66c617869050054f91643739a7e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Huige Li
2. U. Förstermann
3. Sven Horke
4. Elina Ikonen
5. G. Hotamışlıgil

In Physiology

1. Huige Li
2. U. Förstermann
3. Sven Horke
4. M. Schwartz
5. Elina Ikonen
6. G. Hotamışlıgil
7. Haiming Cao
8. R. Medzhitov

In Surgery

1. M. Schwartz
2. U. Förstermann
3. Elina Ikonen
4. G. Hotamışlıgil
5. C. Hetz

Citations in the corpus

• The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “Lipids are macromolecules that exhibit various types and complex structures, and lipids play important roles in cellular function (Maxfield and Tabas, 2005).”
• Vascular oxidative stress, nitric oxide and atherosclerosis. (2014, background): “At the cellular level, t he named processes converge at a stressed endoplasmic reticulum (ER), as the ER relies on tig ht redox control and tolerates only a precise lipid homeostasis due to its low intrinsic choleste rol levels [6, 7].”
• The Cellular Biology of Macrophages in Atherosclerosis (2011, neutral): “…can have profound effects on macrophages in advanced lesions (discussed below), the influence of cholesteryl ester storage is less certain because it is stored in membrane-bound neutral lipid droplets in the cytoplasm and is thus sequestered from cellular membranes (Maxfield and Tabas, 2005).”
• CHARMM-GUI Membrane Builder for mixed bilayers and its application to yeast membranes. (2009, background): “Moreover, it was reported that for some proteins, the heterogeneity of a membrane is particularly important for protein function (2,20,22).”
• Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, positive): “This latter response is central to the function and survival of macrophages under conditions of lipotoxic stress (Maxfield and Tabas, 2005).”
• Mechanotransduction in vascular physiology and atherogenesis (2009, background): “High levels of cholesterol are carried by low density and very low density lipoproteins (LDLs and VLDLs) to the tissues and contribute to atherosclerosi”
• Cellular cholesterol trafficking and compartmentalization (2008, background): “Moreover, not only is cholesterol important in the pathogenesis of cardiac and brain vascular diseases but it has also been implicated in dementias, diabetes and cancer, as well as several rare monogenic diseases (such as familial hypercholesterolaemia and lysosomal cholesterol–sphingolipid stora”