Angiogenesis in brain tumours

By Rakesh K. Jain, E. di Tomaso, D. Duda, Jay S. Loeffler, A. Sorensen, Tracy T. Batchelor. Nature Reviews Neuroscience, 2007

1,441 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6c15399f9a141902738fb92a7dcdaeec14ba28d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. P. Wen
2. Eric C. Holland
3. D. Louis
4. Kenneth D. Aldape

In Genetics

1. Eric C. Holland
2. Richard J. Gilbertson
3. F. Fack

In Molecular Biology

1. Eric C. Holland
2. P. Wen
3. Richard J. Gilbertson
4. D. Louis
5. Kenneth D. Aldape
6. V. Chiono

Citations in the corpus

• Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer (2010, neutral): “2 mm(2)), whereas historically, significant integrity changes were primarily associated with large lesions (>1–4-mm diameter), in which diffusion distances compromise oxygen and nutrient delivery and lead to angiogenesis (66).”
• Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. (2011, background): “Studies have shown that tumor heterogeneity affects most critical tumor properties such as metastatic potential (Yachida et al., 2010), acquired resistance to therapy (Yip et al., 2009), and angiogenic potential (Jain et al., 2007).”
• Exciting New Advances in Neuro-Oncology (2010, background): “53 , 54 The process is driven primarily by tumor-secreted VEGF-A, but there are a large number of alternative secreted proangiogenic factors, including basic FGF (bFGF), angiopoietins, PDGF, interleukin-8 (IL-8), and hepatocyte growth factor/scatter factor (HGF/SF).”
• The brain tumor microenvironment (2011, background): “Vasculogenesis involves the de novo formation of blood vessels that utilize bone marrow-derived endothelial progenitor cells (Jain et al., 2007).”
• Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy (2011, neutral): “The data show the basic angiogenic dynamics seen in superficial tissues 27 are not specific to those areas and reveal the kinetics with which vascular morphology and flow speeds evolve during glioma progression.”
• 3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “Loss of BBB integrity is associated with Alzheimer's disease [4,5], Parkinson's disease [6], and multiple sclerosis [7], as well as with brain cancer [8].”
• The blood-brain barrier in brain homeostasis and neurological diseases. (2009, neutral): “Recent data showed that VEGF, an angiogenic growth factor known to be produced at a high level in brain tumors [147,148], promoted endocytosis of the endothelial cell adhesion molecule VE-cadherin, leading to disruption of the endothelial barrier function and increase in endothelial permeability…”
• Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma (2011, background): “flow and oxygenation (normalization hypothesis) (1, 21, 36).”
• Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells (2009, neutral): “Because VEGF can support brain tumor angiogenesis through regulation of endothelial cell proliferation and survival (Jain et al., 2007; Plate et al., 1992), we examined if knockdown of HIFs in glioblastoma stem and non-stem cells could significantly impact endothelial cell growth (Figures 7F–7H).”