Cellular abnormalities of blood vessels as targets in cancer.

By P. Baluk, H. Hashizume, D. McDonald. Current Opinion in Genetics and Development, 2005

809 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1859bdadd175a4ac23c45d1a660404a99ca6bd69

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Citations in the corpus

The brain tumor microenvironment (2011, background): “Moreover, tumor vasculature with pericyte coverage is better protected than naked regions of the endothelium against antiangiogenic therapies targeted to the endothelium (Baluk et al., 2005).”
Hallmarks of cancer: the next generation. (2011, unknown): “The blood vessels produced within tumors by chronically activated angiogenesis and an unbalanced mix of proangiogenic signals are typically aberrant: tumor neovasculature is marked by precocious capillary sprouting, convoluted and excessive vessel branching, distorted and enlarged vessels, erratic b”
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization (2009, unknown): “…a regular, orderly formed, single EC monolayer with cobblestone appearance (resembling a ''phalanx'' of the Greek military formation), which was continuous and tightly packed, with a normal polarity and few fenestrations (Figures 4F–4H), as a quiescent endothelium (Baluk et al., 2005; Jain, 2005).”
Modes of resistance to anti-angiogenic therapy (2008, background): “Notably, the morphology of these surviving tumour vessels is readily distinguishable from the typically dilated tumour vessels of untreated animals, which are, by contrast, variably covered with less closely associated pericyte”
Integrins in cancer: biological implications and therapeutic opportunities (2010, unknown): “Tumours typically express immature blood vessels with reduced perivascular coverag”
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways. (2012, background): “leakiness, apoptosis and abnormal levels of endothelial cell proliferation.(85) One of the most important characteristics of the process of angiogenesis is its induction in the early stages of carcinogenesis, even in precancerous phases, and its maintenance throughout the tumor development and metas”
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, result): “Other studies noted the absence of pericytes in some capillaries with intact endothelial cells and that vessels with microaneurysms tended to have no pericytes (Barber et al., 2011).”