Fundamentals of cancer metabolism

By Ralph J. Deberardinis, Navdeep S. Chandel. Science Advances, 2016

2,573 citations recorded by the source corpus.

Researchers provide a conceptual framework to understand current knowledge of the fundamentals of cancer metabolism. Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. In this perspective, we provide a conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis. Understanding these concepts will progressively support the development of new strategies to treat human cancer.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bebecd5b21653ab07940aa17ec319c54e710f9dc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy. (2020, background): “This poor vascular exchange can result in nutrient limitation in the TME, while the bioenergetic demands of rapidly proliferating cancer and immune cells compete for nutrients necessary to carry out an anti-tumor defense (De Berardinis & Chandel, 2016; Pavlova & Thompson, 2016).”
Branched Chain Amino Acids: Beyond Nutrition Metabolism (2018, background): “As essential nutrients for cancer growth, BCAAs are utilized by tumors in various biosynthetic pathways and as an energy source of cancer cells [110].”
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches (2019, background): “This high glycolytic metabolism supplies precursors for biomolecules in cellular structure and processes allowing cell survival and proliferation (174, 175).”
CPT1A-mediated fat oxidation, mechanisms and therapeutic potential. (2020, background): “The ability to survive harsh environments is a characteristic of successful cancer cells (122,123).”
Understanding the intersections between metabolism and cancer biology (2017, neutral): “Instead, respiration and other mitochondrial activities are required for tumor growth (DeBerardinis and Chandel, 2016).”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “Metabolic reprogramming is one of the major features of cancer, during which characteristics of metabolic enzymes, upstream regulating molecules and downstream metabolic products, known as metabolites, are altered (DeBerardinis et al., 2008b; Heiden et al., 2009; Jones and Thompson, 2009; Hanahan an”
Metabolic Instruction of Immunity (2017, positive): “The use of asparaginase for acute lymphoblastic leukemia treatment highlights the potential for the depletion of extracellular arginine to significantly affect cellular function (DeBerardinis and Chandel, 2016).”
Revisiting the hallmarks of cancer. (2017, positive): “The mechanisms by which autophagy suppresses tumorigenesis are still elusive, but may include selective elimi- nation of damaged mitochondria during periods of stress reducing the burden of reactive oxygen species (ROS), metabolic homeostasis, degradation of overexpressed proteins, sharing in immune”
Emerging functions of the EGFR in cancer (2017, background): “…rate-limiting enzymes (Lim et al., 2016; Zhang et al., 2017), or indirectly through activation of the MYC transcription factor and of the AKT signaling cascade (Babic et al., 2013; Guo et al., 2009; Makinoshima et al., 2014, 2015, and reviewed in DeBerardinis and Chandel, 2016; Masui et al., 2014).”