Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers.

By You Han Bae, Kazunori Kataoka. Advanced Drug Delivery Reviews, 2009

603 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Biocompatibility of engineered nanoparticles for drug delivery. (2013, background): “ity, only a small number of them havemoved to the clinical studies [163] such as the pH-responsive polymeric micelles [164–169].”
Polymer nanogels: a versatile nanoscopic drug delivery platform (2012, background): “This is because percent loading is representative of a thermodynamic distribution coefficient of the drug in the delivery carrier in preference to the surrounding aqueous environment, while encapsulation stability in a complex environment like the body, is determined by equilibrium rates of drug exc”
Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications (2016, positive): “[114] Similarly, PEG-b-poly(aspartic acid) diblock copolymers linked to doxorubicin via hydrazine linkage, released doxorubicin in acidic pH of tumor.[115] Release of drug-linked PEG depends upon the type of linkage between drug and PEG – permanent or releasable.”
Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery (2017, background): “The increased drug release rate in the acidic medium attributes to the acid-cleavable hydrazone linkage between the DOX and micelles(Bae & Kataoka, 2009).”