Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers.

By Rakesh K. Jain. Journal of Clinical Oncology, 2013

1,092 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cancer Research, Genetics

View Paper: https://www.semanticscholar.org/paper/8d0b09ba2d1d647256924890652dc47074fced15

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. O. Farokhzad
2. Rakesh K. Jain
3. Triantafyllos Stylianopoulos
4. John D. Martin
5. H. Maeda
6. S. Barry
7. T. Lammers
8. Eva M. Sevick-Muraca

In Cancer Research

1. Triantafyllos Stylianopoulos
2. John D. Martin
3. Rakesh K. Jain
4. O. Farokhzad
5. H. Maeda
6. S. Barry
7. T. Lammers
8. C. Mantzoros

In Genetics

1. Triantafyllos Stylianopoulos
2. John D. Martin
3. S. Barry
4. Rakesh K. Jain

Citations in the corpus

• Extracellular matrix structure. (2016, background): “penetration and efficacy of administrated therapeutic agents in tumors [355].”
• Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “Anti-angiogenic drugs are traditionally used to deprive tumors from oxygen and nutrients [61].”
• Challenges and key considerations of the enhanced permeability and retention (EPR) effect for nanomedicine drug delivery in oncology (2013, positive): “Jain (Harvard Medical School, Boston, Massachusetts); hypothesized that normalizing the vasculature, extracellular matrix, and lymphatics will lead to better delivery of drugs (9).”
• Obesity and cancer risk: Emerging biological mechanisms and perspectives. (2019, background): “Tumor progression in obesity-related malignancies implicates IR, inflammation and tumor infiltration with immune cells [113].”
• Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels (2013, neutral): “…data notwithstanding, it should be noted that antiangiogenic therapy with bevacizumab has failed to prolong survival in desmoplastic tumours such as breast and pancreatic cancer 3 , casting doubt on a possible antiangiogenic mechanism for the benefits observed with angiotensin inhibitors.”
• ANTIANGIOGENESIS STRATEGIES REVISITED: FROM STARVING TUMORS TO ALLEVIATING HYPOXIA (2014, positive): “Additionally, agents that can normalize both desmoplastic stroma and abnormal blood vessels may be effective in these treatment-resistant tumors (Stylianopoulos and Jain, 2013).”
• Recent Advances in Biosensor Technology for Potential Applications – An Overview (2016, background): “Quantum dots technology can be applied to understand the tumor microenvironment for therapeutics and also for the delivery of nano-medicine (Jain, 2013).”