Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

By C. Combadière, Stephane Potteaux, M. Rodero, T. Simon, A. Pézard, B. Esposito, R. Merval, A. Proudfoot, A. Tedgui, Z. Mallat. Circulation, 2008

710 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/e6a91f887f02b70af5ec5392be4080db15362f8a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Peter Libby
2. Christian Weber
3. C. Shi
4. Eric G. Pamer
5. A. Zernecke
6. H. Noels
7. G. Hansson
8. Y. Belkaid

In Oncology

1. Peter Libby
2. Eric G. Pamer

Citations in the corpus

• International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “An additive effect with Ccr5 and Cx3cr1 has been demonstrated (Combadiere et al., 2008).”
• Macrophage Phenotype and Function in Different Stages of Atherosclerosis (2016, neutral): “Other monocyte receptors playing a role in the recruitment of monocytes into lesions of atherosclerosis under different conditions include CCR1, CCR5, and CX3CR1.(78,79) The list of cytokines and chemokines promoting atherosclerosis in mice has grown considerably.”
• Atherosclerosis: current pathogenesis and therapeutic options (2011, background): “Genetic deletion of CCL2 and CX3CR1, or CCR2 and CX3CL1 decreases atherosclerosis compared with single deficiencies in these proteins, which is attributable to both attenuated hyperlipidemia-associated blood monocytosis and reduced macrophage accumulatio”
• The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models (2008, result): “By contrast, recent data indicate that CCL2, CX 3 CR1 and CCR5 cooperate in mobilizing monocytes from the bone marrow to cause monocytosis and atheroprogression in Apoe −/− mic”
• Monocyte recruitment during infection and inflammation (2011, background): “Combined inhibition of CCL2, CCR5 and CX 3 CR1 signalling abrogated monocyte recruitment and almost abolished atherosclerosis in Apoe −/− mice, which are predisposed to the diseas”