Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes
By S. Bekkering, J. Quintin, L. Joosten, J. V. D. van der Meer, Mihai G. Netea, N. Riksen. Arteriosclerosis, Thrombosis and Vascular Biology, 2014
619 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/156d98368daed38c29fda193a77c6e875a7129f3
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- A. Lichtman
- I. Tabas
- Mihai G. Netea
- L. Joosten
- K. Mills
- Joachim L. Schultze
- F. L. van de Veerdonk
- G. Natoli
Citations in the corpus
- Monocyte-Macrophages and T Cells in Atherosclerosis (2017, positive): “There is also evidence that metabolic conditions can induce epigenetic changes in macrophages and thus lead to a form of innate immune memory (‘‘trained immunity’’) (Netea et al., 2016; Phan et al., 2017) that might promote lesion progression (Bekkering et al., 2016).”
- Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming (2018, methodology): “We used the pro-inflammatory oxidized form of LDL (oxLDL) that has been associated with WD and is known to induce trained immunity in human monocytes (Bekkering et al., 2014).”
- Trained immunity: a program of innate immune memory in health and disease (2016, background): “A strong argument for this hypothesis is the recent demonstration of trained immunity induced by oxidized LDL in human monocytes via epigenetic reprogramming (105).”
- BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. (2018, background): “Intriguingly, the receptor of oxidized low-density lipoprotein (oxLDL), OLR1, a marker of atherosclerosis, previously shown to induce a long-term pro-inflammatory phenotype in monocytes (Bekkering et al., 2014), was also differentially regulated upon BCG vaccination (Table S3).”
- Metabolic Induction of Trained Immunity through the Mevalonate Pathway. (2018, positive): “Indeed, mevalonate induced an enrichment of H3K4me3 on the promoters of IL6 and TNFA (Figure 2G), similar to the training by b-glucan and oxLDL (Bekkering et al., 2014; Quintin et al., 2012).”
- Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases (2019, background): “For instance, in vitro exposure of human monocytes to oxidized low density lipoprotein (oxLDL) reprograms the cells to enhance the expression of pro-inflammatory cytokines and chemokines (66).”