Interleukin-12 and the regulation of innate resistance and adaptive immunity

By G. Trinchieri. 2003

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In Immunology

Citations in the corpus

Immunoregulatory Functions of mTOR Inhibition (2009, background): “The coordinated secretion of pro- and anti-inflammatory cytokines is essential for effective immune response”
IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis (2007, background): “It is a 70-kDa heterodimeric secreted protein consisting of two disulfide-linked subunits, designated p35 and p40, which are products of distinct genes (11).”
CD28− T cells: their role in the age-associated decline of immune function (2009, background): “Sun Z, et al. Association of Graves’ disease and prevalence of circulating IFN-gamma-producing CD28(−) T cells.”
TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 (2007, background): “Before the discovery of IL-23 and IL-27, IL-12 (comprised of the IL12p40 and IL12p35 subunits) was thought to cause several chronic inflammatory diseases because it induces the differentiation of naive T cells toward an IFN-γ–secreting T H 1 phenotyp”
A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007, neutral): “IFN-γ has both a direct toxic effect on cancer cells and antiangiogenic activity (82).”
Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab (2011, background): “T H 1 responses are thought to promote cell-mediated immunity to intracellular pathogens, delayed type hypersensitivity and macrophage activatio”
Intraepithelial type 1 innate lymphoid cells are a unique subset of cytokine responsive interferon-γ-producing cells (2013, neutral): “Because IL-12 induces IFN-g production by intraepithelial ILC1 (see Figure 1) and is secreted by inflammatory monocytes, macrophages, and dendritic cells (DCs) (Trinchieri, 2003), we asked whether NKp44CD103 ILC1 produce IFN-g in response to signals generated by monocytes and monocyte-derived DC.”
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. (2021, result): “Consistent with previous finding (Maier et al., 2020), IL12B, which could induce the differentiation of T helper 1 (TH1) cells (Trinchieri, 2003), was specific to cDC1-derived LAMP3+ cDCs (Figures 4D and S5F). cDC1-derived LAMP3+ cDCs also showed higher expression of BTLA (Figures 4D and S5F),…”
Dendritic cells: translating innate to adaptive immunity. (2006, background): “In addition, innate lymphocytes and interferons act back on the DCs to drive maturation, and on T and B lymphocytes to enhance adaptive immunity (reviewed in [8, 9]).”
Macrophage activation and polarization. (2008, background): “M1 macrophages display widespread morphology depending on their tissue location, but are accumunated by their ability to secrete significant amount of proinflammatory cytokines, such as IL-1beta, IL-15, IL-18, TNFalpha, and IL-12, a covalently linked heterodimer formed by a light chain of approximat”
STATs in cancer inflammation and immunity: a leading role for STAT3 (2009, neutral): “by antagonizing NF-κB- and STAT1 -mediated expression of anti-tumour T helper 1 ( T H 1 ) cytokines such as IL-12 and interferon-γ ( IFNγ ), which are necessary for both innate and T cell-mediated anti-tumour immunit”