A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells.
By Si Cheng, Ziyi Li, Ranran Gao, B. Xing, Yu-nong Gao, Yu Yang, Shishang Qin, Lei Zhang, Hanqiang Ouyang, Peng Du and 10 more. Cell, 2021
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Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the similarity and distinction of their fundamental properties across different tumors remain elusive. Here, by performing a pan-cancer analysis of single myeloid cells from 210 patients across 15 human cancer types, we identified distinct features of TIMs across cancer types. Mast cells in nasopharyngeal cancer were found to be associated with better prognosis and exhibited an anti-tumor phenotype with a high ratio of TNF+/VEGFA+ cells. Systematic comparison between cDC1- and cDC2-derived LAMP3+ cDCs revealed their differences in transcription factors and external stimulus. Additionally, pro-angiogenic tumor-associated macrophages (TAMs) were characterized with diverse markers across different cancer types, and the composition of TIMs appeared to be associated with certain features of somatic mutations and gene expressions. Our results provide a systematic view of the highly heterogeneous TIMs and suggest future avenues for rational, targeted immunotherapies.
Subfields: Immunology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/dad752811d3fe01bc8354c8a4e086777b8fc286d
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- Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2024 (2023, background): “Moreover, single-cell sequencing technologies have emerged as powerful tools to study cellular heterogeneity ( 5 ), developmental processes ( 6 ), disease mechanisms ( 7 ), and complex biological systems ( 8 ) with unprecedented resolution ( 9 ).”
- Single-cell landscape of peripheral and tumor-infiltrating immune cells in HPV-negative HNSCC (2025, unknown): “45,46 52-54 Regarding the pathological stage, we again found that most of the upregulated DEGs in cells from individuals with tumors at a higher stage of progression (T3 or T4) are related to the response to interferon, with the most frequent being IFIT1, IFI44, IFI44L and IFIT3, however not mainly…”