Immunoregulatory Functions of mTOR Inhibition

By A. Thomson, H. Turnquist, G. Raimondi. Nature reviews. Immunology, 2009

877 citations recorded by the source corpus.

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of growth factor-induced T cell proliferation. However, it is now evident that the serine/threonine protein kinase mammalian target of rapamycin (mTOR) has an important role in the modulation of both innate and adaptive immune responses. mTOR regulates diverse functions of professional antigen-presenting cells, such as dendritic cells (DCs), and has important roles in the activation of effector T cells and the function and proliferation of regulatory T cells. In this Review, we discuss our current understanding of the mTOR pathway and the consequences of mTOR inhibition, both in DCs and T cells, including new data on the regulation of forkhead box P3 expression.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a5b9cfbc1e6826918c7a04ec0867d6b927aa8ce7

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Citations in the corpus

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, neutral): “This pathway is inhibited by rapamycin, which blocks the function of a serine and threonine kinase, mTOR (mechanistic target of rapamycin), which is activated by PI-3KAKT pathway (Thomson et al., 2009).”
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway (2016, background): “Rapamycin and its derivatives are currently used for the prevention of kidney transplant rejection, the treatment of graft-versushost disease, and the chemotherapy of some cancers (11).”
Regulation of Immune Responses by mTOR (2011, background): “For example, growth factors such as insulin or insulin-like growth factor lead to the activation of phosphatidylinositol 3-kinase (PI3K) that through the production of phosphatidylinositol (3,4,5)-trisphosphate (PIP3) will activate 3-phosphoinositide-dependent protein kinase-1 (PDK1), which in turn ”
Human nutrition, the gut microbiome, and immune system: envisioning the future (2011, background): “Examples are the serine/threonine kinase mammalian target of rapamycin (mTOR”